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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Syn1tm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:1857250
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Syn1tm1Sud/Syn1tm1Sud involves: 129S7/SvEvBrd MGI:3032586
cx2
 		Syn1tm1Sud/Syn1tm1Sud
Syn2tm1Sud/Syn2tm1Sud 		involves: 129S7/SvEvBrd MGI:3032602
cx3
 		Syn1tm1Sud/Syn1tm1Sud
Tg(Camk2a-HRAS*G12V)1Sva/0 		involves: 129S7/SvEvBrd * 129T2/SvEmsJ * C57BL/6 * C57BL/6N MGI:4360264


Genotype
MGI:3032586
hm1
Allelic
Composition		 Syn1tm1Sud/Syn1tm1Sud
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn1tm1Sud mutation (1 available); any Syn1 mutation (22 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
convulsive seizures ( J:15701 )
• seizure activity begins after 2 months of age

nervous system
convulsive seizures ( J:15701 )
• seizure activity begins after 2 months of age
enhanced paired-pulse facilitation ( J:15701 )
• enhancement of mean paired pulse facilitation (PPF)




Genotype
MGI:3032602
cx2
Allelic
Composition		 Syn1tm1Sud/Syn1tm1Sud
Syn2tm1Sud/Syn2tm1Sud
Genetic
Background		 involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn1tm1Sud mutation (1 available); any Syn1 mutation (22 available)
Syn2tm1Sud mutation (1 available); any Syn2 mutation (23 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
behavior/neurological
convulsive seizures ( J:26920 )
• seizure activity begins after 2 months of age

nervous system
convulsive seizures ( J:26920 )
• seizure activity begins after 2 months of age




Genotype
MGI:4360264
cx3
Allelic
Composition		 Syn1tm1Sud/Syn1tm1Sud
Tg(Camk2a-HRAS*G12V)1Sva/0
Genetic
Background		 involves: 129S7/SvEvBrd * 129T2/SvEmsJ * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn1tm1Sud mutation (1 available); any Syn1 mutation (22 available)
Tg(Camk2a-HRAS*G12V)1Sva mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:102160 )
N
• mice exhibit normal presynaptic plasticity during tetanus, magnitude of long term potentiation, cumulative probability distribution, and contextual conditioning




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
09/30/2025
MGI 6.24 		The Jackson Laboratory