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Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID
Syn1tm1Sud
targeted mutation 1, Thomas C Sudhof
MGI:1857250
Summary 3 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
Syn1tm1Sud/Syn1tm1Sud involves: 129S7/SvEvBrd MGI:3032586
cx2
Syn1tm1Sud/Syn1tm1Sud
Syn2tm1Sud/Syn2tm1Sud
involves: 129S7/SvEvBrd MGI:3032602
cx3
Syn1tm1Sud/Syn1tm1Sud
Tg(Camk2a-HRAS*G12V)1Sva/0
involves: 129S7/SvEvBrd * 129T2/SvEmsJ * C57BL/6 * C57BL/6N MGI:4360264


Genotype
MGI:3032586
hm1
Allelic
Composition
Syn1tm1Sud/Syn1tm1Sud
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn1tm1Sud mutation (1 available); any Syn1 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• seizure activity begins after 2 months of age

nervous system
• seizure activity begins after 2 months of age
• enhancement of mean paired pulse facilitation (PPF)




Genotype
MGI:3032602
cx2
Allelic
Composition
Syn1tm1Sud/Syn1tm1Sud
Syn2tm1Sud/Syn2tm1Sud
Genetic
Background
involves: 129S7/SvEvBrd
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn1tm1Sud mutation (1 available); any Syn1 mutation (22 available)
Syn2tm1Sud mutation (1 available); any Syn2 mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
• seizure activity begins after 2 months of age

nervous system
• seizure activity begins after 2 months of age




Genotype
MGI:4360264
cx3
Allelic
Composition
Syn1tm1Sud/Syn1tm1Sud
Tg(Camk2a-HRAS*G12V)1Sva/0
Genetic
Background
involves: 129S7/SvEvBrd * 129T2/SvEmsJ * C57BL/6 * C57BL/6N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Syn1tm1Sud mutation (1 available); any Syn1 mutation (22 available)
Tg(Camk2a-HRAS*G12V)1Sva mutation (0 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
nervous system
N
• mice exhibit normal presynaptic plasticity during tetanus, magnitude of long term potentiation, cumulative probability distribution, and contextual conditioning





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last database update
04/30/2024
MGI 6.23
The Jackson Laboratory