All Phenotypes Cd40lg<tm1Imx> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Cd40lg^tm1Imx
targeted mutation 1, Immunex
MGI:1857145

Summary

6 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd40lg^tm1Imx/Cd40lg^tm1Imx	involves: 129S2/SvPas * C57BL/6	MGI:3712666
hm2	Cd40lg^tm1Imx/Cd40lg^tm1Imx	involves: 129S2/SvPas * C57BL/6J * BALB/c	MGI:3652977
ot3	Cd40lg^tm1Imx/Y	B6.129S2-Cd40lg^tm1Imx/J	MGI:3712657
ot4	Cd40lg^tm1Imx/Y	involves: 129S2/SvPas * C57BL/6	MGI:2449491
ot5	Cd40lg^tm1Imx/?	B6.129S2-Cd40lg^tm1Imx/J	MGI:5437216
ot6	Cd40lg^tm1Imx/?	involves: 129S2/SvPas * C57BL/6	MGI:5437219

Allelic Composition	Cd40lg^tm1Imx/Cd40lg^tm1Imx
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Imx mutation (4 available); any Cd40lg mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

reproductive system phenotype ( J:21137 )

N	• homozygous females are viable and fertile

homeostasis/metabolism

abnormal blood coagulation ( J:75152 )

• thrombi formed in response to FeCl3 injury are fragile and prone to rupture and to embolizing

• smaller thrombi with lower platelet density

• clotting times are normal

immune system

microgliosis ( J:115487 )

• increased microgliosis

increased susceptibility to prion infection ( J:115487 )

• early onset of disease when infected with scrapie

• succumb to infection after 144 days as opposed to 184 days for controls

• symptoms of scrapie infection equivalent to 1000X higher dose

nervous system

microgliosis ( J:115487 )

• increased microgliosis

loss of cortex neurons ( J:115487 )

• more severe loss of parvalbumin positive neurons in the cortex as a result of scrapie infection than occurs in controls

neurodegeneration ( J:115487 )

• increased apoptosis

spongiform encephalopathy ( J:115487 )

• vacuolation resulting from scrapie infection more pronounced than in controls

abnormal nervous system physiology ( J:115487 )

hematopoietic system

microgliosis ( J:115487 )

• increased microgliosis

Allelic Composition	Cd40lg^tm1Imx/Cd40lg^tm1Imx
Genetic Background	involves: 129S2/SvPas * C57BL/6J * BALB/c

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Imx mutation (4 available); any Cd40lg mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

abnormal T cell clonal deletion ( J:110925 )

• mice show complete rescue of CD8+ and CD4+ V beta11+ and beta6+ bearing CD4+ and CD8+ thymocytes from deletion in the thymus and periphery and Vbeta5+ CD4+ cells, but not Vbeta5+ bearing CD8+ thymocytes

hematopoietic system

abnormal T cell clonal deletion ( J:110925 )

Allelic Composition	Cd40lg^tm1Imx/Y
Genetic Background	B6.129S2-Cd40lg^tm1Imx/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Imx mutation (4 available); any Cd40lg mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

nervous system

decreased cerebral infarct size ( J:108988 )

• significantly reduced infarct volumes

abnormal thalamus morphology ( J:106362 )

• loss of neurons in the submedial thalamic nucleus due to thiamine deficiency slower than in controls

• after 11 days of thiamine deficiency, neuron loss in the submedial thalamic nucleus due to thiamine deficiency is about 90%

hematopoietic system

abnormal leukocyte adhesion ( J:108988 )

• reduced leukocyte rolling and adhesion

decreased platelet aggregation ( J:108988 )

• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion

homeostasis/metabolism

decreased platelet aggregation ( J:108988 )

• reduced number of rolling platelets and 50% attenuation in platelet adhesion following 1 hour of middle cerebral artery occlusion and 4 hours of reperfusion

decreased cerebral infarct size ( J:108988 )

• significantly reduced infarct volumes

cellular

abnormal leukocyte adhesion ( J:108988 )

• reduced leukocyte rolling and adhesion

immune system

abnormal leukocyte adhesion ( J:108988 )

• reduced leukocyte rolling and adhesion

Allelic Composition	Cd40lg^tm1Imx/Y
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Imx mutation (4 available); any Cd40lg mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

immune system

immune system phenotype ( J:21137 )

N	• serum IgM and IgG3 levels are more or less normal at all ages

abnormal immune system organ morphology ( J:21137 )

absent spleen germinal center ( J:21137 )

• failure to form germinal centers

abnormal lymph node morphology ( J:21137 )

absent lymph node germinal center ( J:21137 )

• failure to form germinal centers in inguinal lymph nodes although primary follicle formation is normal

lymph node hypoplasia ( J:21137 )

• about 1/3 that of controls while overall T and B cell numbers are normal

abnormal immune system physiology ( J:21137 )

abnormal class switch recombination ( J:21137 )

decreased immunoglobulin level ( J:21137 )

decreased IgA level ( J:21137 )

decreased IgE level ( J:21137 )

• undetectable

decreased IgG1 level ( J:21137 )

decreased IgG2b level ( J:21137 )

abnormal antigen presentation ( J:21137 )

• unable to mount a secondary response to TNP-KLH antigen (T cell dependent)

• T cell independent responses are normal as is isotype switching for these antigens

hematopoietic system

abnormal class switch recombination ( J:21137 )

absent spleen germinal center ( J:21137 )

• failure to form germinal centers

decreased immunoglobulin level ( J:21137 )

decreased IgA level ( J:21137 )

decreased IgE level ( J:21137 )

• undetectable

decreased IgG1 level ( J:21137 )

decreased IgG2b level ( J:21137 )

Allelic Composition	Cd40lg^tm1Imx/?
Genetic Background	B6.129S2-Cd40lg^tm1Imx/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Imx mutation (4 available); any Cd40lg mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

skeleton

decreased bone mineral density ( J:145330 )

• significantly reduced

decreased compact bone mass ( J:145330 )

• significantly reduced

decreased trabecular bone mass ( J:145330 )

• significantly reduced

Allelic Composition	Cd40lg^tm1Imx/?
Genetic Background	involves: 129S2/SvPas * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cd40lg^tm1Imx mutation (4 available); any Cd40lg mutation (14 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

homeostasis/metabolism

decreased platelet aggregation ( J:103954 )

• reduced shear induced platelet aggregation

• reduced in vitro platelet aggregation

abnormal thrombosis ( J:103954 )

• significantly delayed blood vessel occlusion

increased bleeding time ( J:103954 )

• significantly prolonged tail vein bleeding times

hematopoietic system

hematopoietic system phenotype ( J:103954 )

N	• normal platelet counts

decreased platelet aggregation ( J:103954 )

• reduced shear induced platelet aggregation

• reduced in vitro platelet aggregation

cardiovascular system

abnormal vascular endothelial cell morphology ( J:115587 )

• carotid artery intimal thickening is increased over controls 21 days after collar placement around the carotid artery

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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