Phenotypes associated with this allele

• Allele Symbol: Cd4^tm1Knw
• Allele Name: targeted mutation 1, Barbara B Knowles
• Allele ID: MGI:1857143
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Cd4^tm1Knw/Cd4^tm1Knw	B6.129S-Cd4^tm1Knw/J	MGI:3580328
hm2	Cd4^tm1Knw/Cd4^tm1Knw	NOD.Cg-Cd4^tm1Knw	MGI:3623373
cx3	Cd4^tm1Knw/Cd4^tm1Knw Tgfb1^tm1Doe/Tgfb1^tm1Doe	involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1	MGI:3622474
cx4	Cd4^tm1Knw/Cd4^tm1Knw Tg(TcraAI4)1Dvs/0 Tg(TcrbAI4)1Dvs/0	NOD.Cg-Cd4^tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs	MGI:3618705

Genotype
MGI:3580328

hm1

• Allelic Composition: Cd4^tm1Knw/Cd4^tm1Knw
• Genetic Background: B6.129S-Cd4^tm1Knw/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:87828 )

• significantly decreased CD4+ cell population in spleen and thymus as compared to control

increased CD8-positive, alpha-beta T cell number ( J:87828 )

• increased CD8+ cell population in spleen and thymus as compared to control

increased susceptibility to parasitic infection ( J:87828 )

• significantly increased clearance time (24-50 days) after infection by Rickettsiales member (E. chaffeensis)

• granulomatous inflammation in liver is more extensive at 16 days post-infection in contrast to control

• delayed CTL response following second challenge with E. chaffeensis infection

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:87828 )

• significantly decreased CD4+ cell population in spleen and thymus as compared to control

increased CD8-positive, alpha-beta T cell number ( J:87828 )

• increased CD8+ cell population in spleen and thymus as compared to control

Genotype
MGI:3623373

hm2

• Allelic Composition: Cd4^tm1Knw/Cd4^tm1Knw
• Genetic Background: NOD.Cg-Cd4^tm1Knw

immune system

decreased susceptibility to autoimmune diabetes ( J:93553 )

• Cd4-deficient mice are diabetes resistant (diabetes observed in 0/18 females by 30 weeks)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	type 1 diabetes mellitus	DOID:9744	OMIM:222100	J:93553

Genotype
MGI:3622474

cx3

• Allelic Composition: Cd4^tm1Knw/Cd4^tm1Knw; Tgfb1^tm1Doe/Tgfb1^tm1Doe
• Genetic Background: involves: 129S/SvEv * 129S2/SvPas * C57BL/6 * CF-1

mortality/aging

premature death ( J:99033 )

• majority of double mutants die by 35 days of age

Genotype
MGI:3618705

cx4

• Allelic Composition: Cd4^tm1Knw/Cd4^tm1Knw; Tg(TcraAI4)1Dvs/0; Tg(TcrbAI4)1Dvs/0
• Genetic Background: NOD.Cg-Cd4^tm1Knw Tg(TcraAI4)1Dvs Tg(TcrbAI4)1Dvs

immune system

increased susceptibility to autoimmune diabetes ( J:93553 )

• transgene-expressing female mice develop IDDM with an onset of about 7 weeks of age, whereas CD4-null NOD mice are resistant (no IDDM by 30 weeks of age)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:93553