Phenotypes associated with this allele

• Allele Symbol: Fndc3a^sys
• Allele Name: symplastic spermatids
• Allele ID: MGI:1857062
• Summary: 3 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fndc3a^sys/Fndc3a^sys	B6.Cg-Fndc3a^sys	MGI:3723486
hm2	Fndc3a^sys/Fndc3a^sys	involves: C3H * FVB/N	MGI:3040934
ht3	Fndc3a^Gt(RRP208)Byg/Fndc3a^sys	involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N	MGI:3723487

Genotype
MGI:3723486

hm1

• Allelic Composition: Fndc3a^sys/Fndc3a^sys
• Genetic Background: B6.Cg-Fndc3a^sys

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

abnormal spermatogenesis ( J:119576 )

♂ • the seminiferous epithelium contains symplasts of spermatids and lacks mature elongated spermatids

♂ • symplasts of spermatids are observed in the material extruded from the vasa deferentia

♂ • caudal epididymides are devoid of mature spermatozoa

male infertility ( J:119576 )

♂

Genotype
MGI:3040934

hm2

• Allelic Composition: Fndc3a^sys/Fndc3a^sys
• Genetic Background: involves: C3H * FVB/N

cellular

multinucleated giant male germ cells ( J:10611 )

♂

endocrine/exocrine glands

abnormal seminiferous tubule morphology ( J:1972 )

♂ • the tubular lumina appears enlarged

♂ • macrophages are seen in the tubular lumina

abnormal Sertoli cell morphology ( J:1972 , J:10611 )

♂ • the body of the Seroli cell is not seen between the round spermatids or when present is smaller than normal (J:1972)

♂ • the Sertoli cells do not maintain a close relationship with the developing spermatids (J:10611)

♂ • the Sertoli cells display extensive intracellular vacuolation (J:10611)

decreased testis weight ( J:1972 , J:10611 )

♂ • adult testes are smaller in weight in mutants compared to wild-type littermates (J:1972)

♂ • adult testes are smaller in weight in mutants compared to wild-type littermates (J:10611)

reproductive system

multinucleated giant male germ cells ( J:10611 )

♂

abnormal seminiferous tubule morphology ( J:1972 )

♂ • the tubular lumina appears enlarged

♂ • macrophages are seen in the tubular lumina

abnormal Sertoli cell morphology ( J:1972 , J:10611 )

♂ • the body of the Seroli cell is not seen between the round spermatids or when present is smaller than normal (J:1972)

♂ • the Sertoli cells do not maintain a close relationship with the developing spermatids (J:10611)

♂ • the Sertoli cells display extensive intracellular vacuolation (J:10611)

decreased testis weight ( J:1972 , J:10611 )

♂ • adult testes are smaller in weight in mutants compared to wild-type littermates (J:1972)

♂ • adult testes are smaller in weight in mutants compared to wild-type littermates (J:10611)

arrest of spermatogenesis ( J:1972 , J:10611 )

♂ • almost all of the round and newly elongating spermatids are grossly abnormal by mid-cycle and then show signs of degeneration (J:1972)

♂ • intercellular bridges that normally exist between developing spermatids widen and contribute to the formation of multinuclear giant cells (J:1972)

♂ • spermiogenesis arrests with the formation of multinucleated giant cells (syncitia) around stage 6 (J:10611)

♂ • many spermatocytes degenerate between stages 2 ? 4 of spermiogenesi (J:10611)

male infertility ( J:1972 , J:10611 )

♂ • males are completely sterile (J:1972)

♂ • males are completely sterile (J:10611)

Genotype
MGI:3723487

ht3

• Allelic Composition: Fndc3a^{Gt(RRP208)Byg}/Fndc3a^sys
• Genetic Background: involves: 129P2/OlaHsd * C3H * C57BL/6 * FVB/N

reproductive system

abnormal spermatogenesis ( J:119576 )

♂ • the seminiferous epithelium contains symplasts of spermatids and lacks mature elongated spermatids similar to those seem in Fndc3a^sys homozygotes

♂ • caudal epididymides are devoid of mature spermatozoa similar to Fndc3a^sys homozygotes

male infertility ( J:119576 )

♂