Fndc3a^sys
Transgenic Allele Detail

Summary

• Symbol: Fndc3a^sys
• Name: fibronectin type III domain containing 3A; symplastic spermatids
• MGI ID: MGI:1857062
• Gene: Fndc3a Location: Chr14:72775386-72947443 bp, - strand Genetic Position: Chr14, 37.62 cM
• Alliance: Fndc3a^sys page

Transgene origin

• Strain of Origin: (FVB/N x C3H)F1

Transgene description

• Transgene Type: Transgenic
• Mutations: Insertion, Intragenic deletion
• Mutation details: Approximately 20 copies of a Rous sarcoma virus long terminal repeat promoter, lacZ mini gene are integrated as a head to tail concatamer at a single site on mouse chromosome 14. There is in addition a deletion of 1.24 Mb of genomic DNA at the transgene insertion site. Fndc3a is contained in the deleted region. Comparative genome analysis of the 1.2 Mb region of chromosome 14 deleted in Fndc3a^sys mice with human 8p21 and 13q14 suggests that Fndc3a is the only gene mutated in Fndc3a^sysmice. (J:119576)
• Inheritance: Recessive

Expression

In Structures Affected by this Mutation:

4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fndc3a Mutation: 69 strains or lines available

References

• Original: J:10611 MacGregor GR, et al., Symplastic spermatids (sys): a recessive insertional mutation in mice causing a defect in spermatogenesis. Proc Natl Acad Sci U S A. 1990 Jul;87(13):5016-20
• All: 3 reference(s)