All Phenotypes Myo15a<sh2> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Myo15a^sh2
shaker 2
MGI:1857036

Summary

5 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Myo15a^sh2/Myo15a^sh2	Mixed stock	MGI:3810335
hm2	Myo15a^sh2/Myo15a^sh2	Not Specified	MGI:3046320
hm3	Myo15a^sh2/Myo15a^sh2	STOCK Myo15a^sh2/J	MGI:6192757
cx4	Myo15a^sh2/Myo15a⁺ Myo6^sv/Myo6⁺	involves: B10.HA/(33NX)Sn	MGI:3528186
cx5	Myo15a^sh2/Myo15a^sh2 Myo6^sv/Myo6^sv	involves: B10.HA/(33NX)Sn	MGI:3528187

Allelic Composition	Myo15a^sh2/Myo15a^sh2
Genetic Background	Mixed stock

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo15a^sh2 mutation (1 available); any Myo15a mutation (136 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal cochlear outer hair cell morphology ( J:158897 )

• most outer hair cells exhibit a non-convex region on their apical circumference unlike wild-type cells

• outer hair cells exhibit a slight flattening of their neural side compared to in wild-type mice

short outer hair cell stereocilia ( J:132633 , J:158897 )

• hair cell stereocilia are shorter than in wild-type mice (J:132633)

nervous system

abnormal cochlear outer hair cell morphology ( J:158897 )

• most outer hair cells exhibit a non-convex region on their apical circumference unlike wild-type cells

• outer hair cells exhibit a slight flattening of their neural side compared to in wild-type mice

short outer hair cell stereocilia ( J:132633 , J:158897 )

• hair cell stereocilia are shorter than in wild-type mice (J:132633)

Allelic Composition	Myo15a^sh2/Myo15a^sh2
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo15a^sh2 mutation (1 available); any Myo15a mutation (136 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal organ of Corti morphology ( J:13046 )

abnormal cochlear hair cell morphology ( J:6873 , J:13046 )

• by 2.5 months of age type 1 hair cells of the crista ampullaris and utricular macula contain rod-shaped inclusions comprising actin filaments (J:6873)

• degeneration is evident in 2 week old mice (J:13046)

organ of Corti degeneration ( J:13046 )

• occurs during the second week

abnormal stria vascularis morphology ( J:13046 )

• evident in 3 week old mutant mice

abnormal tectorial membrane morphology ( J:13046 )

• the membrane is slow to thin to expected dimensions

abnormal utricular macula morphology ( J:13046 )

deafness ( J:13046 )

• due to cochlear degeneration

behavior/neurological

head shaking ( J:13046 )

circling ( J:13046 )

• mutant mice show a tendency to run in circles

nervous system

abnormal cochlear hair cell morphology ( J:6873 , J:13046 )

• by 2.5 months of age type 1 hair cells of the crista ampullaris and utricular macula contain rod-shaped inclusions comprising actin filaments (J:6873)

• degeneration is evident in 2 week old mice (J:13046)

abnormal cochlear ganglion morphology ( J:13046 )

cochlear ganglion degeneration ( J:13046 )

• degeneration is progressive from the time mutants are two weeks old

Allelic Composition	Myo15a^sh2/Myo15a^sh2
Genetic Background	STOCK Myo15a^sh2/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo15a^sh2 mutation (1 available); any Myo15a mutation (136 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

abnormal cochlear hair cell inter-stereocilial links morphology ( J:226820 )

• inner hair cell bundles have immature, omnidirectional links

abnormal inner hair cell stereociliary bundle morphology ( J:226820 )

• hair bundles of inner hair cells have supernumerary stereocilia rows

short inner hair cell stereocilia ( J:226820 )

• inner hair cell bundles are abnormally short

nervous system

abnormal cochlear hair cell inter-stereocilial links morphology ( J:226820 )

• inner hair cell bundles have immature, omnidirectional links

abnormal inner hair cell stereociliary bundle morphology ( J:226820 )

• hair bundles of inner hair cells have supernumerary stereocilia rows

short inner hair cell stereocilia ( J:226820 )

• inner hair cell bundles are abnormally short

Allelic Composition	Myo15a^sh2/Myo15a⁺ Myo6^sv/Myo6⁺
Genetic Background	involves: B10.HA/(33NX)Sn

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Myo15a^sh2 mutation (1 available); any Myo15a mutation (136 available)
Myo6^sv mutation (1 available); any Myo6 mutation (90 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hearing/vestibular/ear

increased susceptibility to age-related hearing loss ( J:86379 )

• slightly increased risk of age related hearing loss

Allelic Composition	Myo15a^sh2/Myo15a^sh2 Myo6^sv/Myo6^sv
Genetic Background	involves: B10.HA/(33NX)Sn

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

growth/size/body

decreased body size ( J:86379 )

• slightly reduced body size

hearing/vestibular/ear

abnormal organ of Corti morphology ( J:86379 )

abnormal cochlear hair cell stereociliary bundle morphology ( J:86379 )

• at 3-4 weeks of age, a few short stereocilia protrude from each hair cell in addition to a single giant stereocilium

short cochlear hair cell stereocilia ( J:86379 )

nervous system

abnormal cochlear hair cell stereociliary bundle morphology ( J:86379 )

• at 3-4 weeks of age, a few short stereocilia protrude from each hair cell in addition to a single giant stereocilium

short cochlear hair cell stereocilia ( J:86379 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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