Phenotypes associated with this allele
Allelic Composition |
Frem2my/Frem2my
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Genetic Background |
involves: MY/HuLeJ * C57BL/6 |
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frem2my mutation
(1 available);
any
Frem2 mutation
(137 available)
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integument
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• subepidermal blistering
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limbs/digits/tail
renal/urinary system
vision/eye
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Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Frem2my mutation
(1 available);
any
Frem2 mutation
(137 available)
|
|
|
mortality/aging
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• some acephalic and extremely pale embryos are found and these are born dead
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vision/eye
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• a clear lesion in the region of the eye is generally found at birth and the severity is greatly variable extending to degeneration of the eye elements
(J:14847)
• in cases where only one eye is abnormal it can be the left or right with no preference for one or the other
(J:14847)
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craniofacial
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• shortened foreface and considerable variation in the length and shape of the foreface can be found
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nervous system
integument
limbs/digits/tail
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• in addition to the eye and facial defects the feet and legs can be impacted to varying degrees including absent, shortened, or malformed digits, hemorrhagic lesions on the digits and legs, twisted foot or paw, or badly distorted leg
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growth/size/body
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• shortened foreface and considerable variation in the length and shape of the foreface can be found
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renal/urinary system
skeleton
embryo
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• Background Sensitivity: many systems are affected with variable penetrance
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