All Phenotypes Zbtb16<lu> MGI Mouse

About Help FAQ

Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Zbtb16^lu
luxoid
MGI:1856943

Summary

8 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Zbtb16^lu/Zbtb16^lu	B10.C3-Zbtb16^lu	MGI:3042590
hm2	Zbtb16^lu/Zbtb16^lu	B6.C3-Zbtb16^Lu	MGI:3042593
hm3	Zbtb16^lu/Zbtb16^lu	B6.C3-Zbtb16^lu/J	MGI:5301113
hm4	Zbtb16^lu/Zbtb16^lu	involves: C3H/He	MGI:3042589
hm5	Zbtb16^lu/Zbtb16^lu	involves: C3H/He * C57BL/6	MGI:4457502
hm6	Zbtb16^lu/Zbtb16^lu	Not Specified	MGI:3042594
ht7	Zbtb16^lu/Zbtb16⁺	B10.C3-Zbtb16^lu	MGI:3042592
ht8	Zbtb16^lu/Zbtb16⁺	involves: C3H/He	MGI:3042591

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	B10.C3-Zbtb16^lu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polyphalangy ( J:13069 )

• incomplete penetrance; the first toe usually has three phalanges

polydactyly ( J:13069 )

• preaxial polydactyly; incomplete penetrance; often an extra preaxial digit is present; up to two extra toes are seen with variable degrees of development; the second or third digit may be split

abnormal tarsal bone morphology ( J:13069 )

long fibula ( J:13069 )

short tibia ( J:13069 )

• less severe than C3H background; results in increased length of the fibula and the shank and foot are not held in the normal position

kinked tail ( J:13069 )

skeleton

polyphalangy ( J:13069 )

• incomplete penetrance; the first toe usually has three phalanges

abnormal tarsal bone morphology ( J:13069 )

long fibula ( J:13069 )

short tibia ( J:13069 )

• less severe than C3H background; results in increased length of the fibula and the shank and foot are not held in the normal position

increased sternebra number ( J:13069 )

• increased number of sternebrae

increased rib number ( J:13069 )

• higher frequency of mice with 14 ribs instead of 13

increased presacral vertebrae number ( J:13069 )

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	B6.C3-Zbtb16^Lu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

endocrine/exocrine glands

small testis ( J:89934 )

• observed in 8 month old mice; suggested to be due to loss of germ cells

reproductive system

decreased male germ cell number ( J:89934 )

• many seminiferous tubules of older mice were agametic, containing only Sertoli cells; other tubules lacked one or more germ cell generations

azoospermia ( J:89934 )

• observed in 8 month old mice

small testis ( J:89934 )

• observed in 8 month old mice; suggested to be due to loss of germ cells

cellular

decreased male germ cell number ( J:89934 )

• many seminiferous tubules of older mice were agametic, containing only Sertoli cells; other tubules lacked one or more germ cell generations

azoospermia ( J:89934 )

• observed in 8 month old mice

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	B6.C3-Zbtb16^lu/J

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

hematopoietic system

decreased NK T cell number ( J:139690 )

• NK T cells are reduced by 90-99% in the thymus, spleen and liver in 4 to 8 week old mice; other lymphocyte populations in the thymus, spleen and lymph node are not affected

immune system

decreased NK T cell number ( J:139690 )

• NK T cells are reduced by 90-99% in the thymus, spleen and liver in 4 to 8 week old mice; other lymphocyte populations in the thymus, spleen and lymph node are not affected

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	involves: C3H/He

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

brachyphalangia ( J:13069 )

• occasional preaxial reduction; hallux is reduced or absent

polyphalangy ( J:13069 )

• incomplete penetrance; the first toe usually has three phalanges

polydactyly ( J:13069 )

• preaxial polydactyly; incomplete penetrance; less frequent than on the C57BL/10 background; often an extra preaxial digit is present; up to two extra toes are seen with variable degrees of development; the second or third digit may be split

abnormal tarsal bone morphology ( J:13069 )

bowed fibula ( J:13069 )

• curved

long fibula ( J:13069 )

short tibia ( J:13069 )

• results in the curvature of the fibula and the knee and heel are brought close together

kinked tail ( J:13069 )

skeleton

brachyphalangia ( J:13069 )

• occasional preaxial reduction; hallux is reduced or absent

polyphalangy ( J:13069 )

• incomplete penetrance; the first toe usually has three phalanges

abnormal tarsal bone morphology ( J:13069 )

bowed fibula ( J:13069 )

• curved

long fibula ( J:13069 )

short tibia ( J:13069 )

• results in the curvature of the fibula and the knee and heel are brought close together

increased sternebra number ( J:13069 )

• increased number of sternebrae

increased rib number ( J:13069 )

• higher frequency of mice with 14 ribs instead of 13

increased presacral vertebrae number ( J:13069 )

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	involves: C3H/He * C57BL/6

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

seminiferous tubule degeneration ( J:160477 )

• dramatic germ cell loss (Sertoli Cell only tubules) even at 3 months of age

• over 50% of tubules are PCNA-negative at 8 months of age

endocrine/exocrine glands

seminiferous tubule degeneration ( J:160477 )

• dramatic germ cell loss (Sertoli Cell only tubules) even at 3 months of age

• over 50% of tubules are PCNA-negative at 8 months of age

Allelic Composition	Zbtb16^lu/Zbtb16^lu
Genetic Background	Not Specified

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

reproductive system

azoospermia ( J:5206 )

• lack of spermatogonia after 6 weeks of age; production of spermatogonia is normal at birth, then a rapid loss of germline cells occurs

male infertility ( J:5206 )

cellular

azoospermia ( J:5206 )

• lack of spermatogonia after 6 weeks of age; production of spermatogonia is normal at birth, then a rapid loss of germline cells occurs

Allelic Composition	Zbtb16^lu/Zbtb16⁺
Genetic Background	B10.C3-Zbtb16^lu

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polyphalangy ( J:13069 )

• incomplete penetrance on hind limb only; the first toe is the usually the only one affected, with either an elongated second phalanx or having three phalanges

polydactyly ( J:13069 )

• preaxial polydactyly; incomplete penetrance on hind limb only; up to two extra toes are seen with variable degrees of development

skeleton

polyphalangy ( J:13069 )

• incomplete penetrance on hind limb only; the first toe is the usually the only one affected, with either an elongated second phalanx or having three phalanges

increased sternebra number ( J:13069 )

• increased number of sternebrae

increased rib number ( J:13069 )

• higher frequency of mice with 14 ribs instead of 13

increased presacral vertebrae number ( J:13069 )

Allelic Composition	Zbtb16^lu/Zbtb16⁺
Genetic Background	involves: C3H/He

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Zbtb16^lu mutation (1 available); any Zbtb16 mutation (30 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

limbs/digits/tail

polyphalangy ( J:13069 )

• incomplete penetrance on hind limb only; the first toe is the usually the only one affected, with either an elongated second phalanx or having three phalanges

skeleton

polyphalangy ( J:13069 )

• incomplete penetrance on hind limb only; the first toe is the usually the only one affected, with either an elongated second phalanx or having three phalanges

increased sternebra number ( J:13069 )

• increased number of sternebrae

increased rib number ( J:13069 )

• higher frequency of mice with 14 ribs instead of 13

increased presacral vertebrae number ( J:13069 )

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 04/23/2024 MGI 6.23