Phenotypes associated with this allele

• Allele Symbol: hy1
• Allele Name: hydrocephalus 1
• Allele ID: MGI:1856911
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	hy1/hy1	involves: C57BL/Li	MGI:4414753
hm2	hy1/hy1	Not Specified	MGI:4414757

Genotype
MGI:4414753

hm1

• Allelic Composition: hy1/hy1
• Genetic Background: involves: C57BL/Li

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality ( J:15010 )

• affected mice die at 3-4 weeks of age

nervous system

hydrocephaly ( J:15010 )

• obvious after one or two weeks

growth/size/body

abnormal head morphology ( J:15010 )

• slight swelling noticeable at birth

Genotype
MGI:4414757

hm2

• Allelic Composition: hy1/hy1
• Genetic Background: Not Specified

mortality/aging

decreased survivor rate ( J:12162 )

• only a few live until sexual maturity, these are of normal size and fertile

• most die between 20 and 40 days of age

nervous system

abnormal brain ventricular system morphology ( J:29152 )

• the entire ventricular system is dilated

hydrocephaly ( J:12162 )

• time of expression is variable, from at birth to 12-15 days of age

obstructive hydrocephaly ( J:12162 )

cerebral aqueductal stenosis ( J:12162 )

• the aqueduct of Sylvius is occluded

dilated lateral ventricle ( J:12162 )

dilated third ventricle ( J:12162 )

abnormal cerebral hemisphere morphology ( J:12162 )

• in some cases pressure of accumulated intraventricular fluid has ruptured the hemispheres

abnormal corpus callosum morphology ( J:12162 )

decreased corpus callosum size ( J:12162 )

• in extreme cases

absent corpus callosum ( J:12162 )

• in extreme cases

thin cerebral cortex ( J:12162 )

abnormal cerebellum morphology ( J:12162 )

• deformed and, in extreme cases, flattened

abnormal subarachnoid space morphology ( J:12162 )

• fills with intraventricular fluid giving appearance of external hydrocephalus

• blood spots are present over the hemispheres

behavior/neurological

increased aggression towards mice ( J:12162 )

• affected mice bite without provocation

nervous ( J:12162 )