Phenotypes associated with this allele

• Allele Symbol: Fgfr2^svs
• Allele Name: seminal vesicle shape
• Allele ID: MGI:1856633
• Summary: 4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Fgfr2^svs/Fgfr2^svs	either: CXB1/By or CXB1/ByEss * CXB1/ByLac	MGI:5620009
hm2	Fgfr2^svs/Fgfr2^svs	involves: CXB5/ByJ	MGI:3705088
ht3	Fgfr2^tm1Dor/Fgfr2^svs	involves: 129X1/SvJ * CXB5/ByJ * FVB/N	MGI:3705020
ht4	Fgfr2^tm1.1Dor/Fgfr2^svs	involves: 129X1/SvJ * CXB5/ByJ * FVB/N	MGI:3705023

Genotype
MGI:5620009

hm1

• Allelic Composition: Fgfr2^svs/Fgfr2^svs
• Genetic Background: either: CXB1/By or CXB1/ByEss * CXB1/ByLac

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

abnormal seminal vesicle morphology ( J:9441 )

♂ • seminal vesicles of postpubertal males of this background are tubular with a smooth surface compared with seminal vesicles of postpubertal males of strains BALB/cByEss and C57BL/6ByEss that are curved and have a convoluted surface

♂ • seminal vesicles of males of progenitor inbred strains BALB/cBy and C57BL/6By mice are tubular

reproductive system

abnormal seminal vesicle morphology ( J:9441 )

♂ • seminal vesicles of postpubertal males of this background are tubular with a smooth surface compared with seminal vesicles of postpubertal males of strains BALB/cByEss and C57BL/6ByEss that are curved and have a convoluted surface

♂ • seminal vesicles of males of progenitor inbred strains BALB/cBy and C57BL/6By mice are tubular

Genotype
MGI:3705088

hm2

• Allelic Composition: Fgfr2^svs/Fgfr2^svs
• Genetic Background: involves: CXB5/ByJ

endocrine/exocrine glands

abnormal prostate gland branching morphogenesis ( J:82767 )

♂ • branching morphogenesis is decreased compared to controls

decreased prostate gland duct number ( J:82767 )

♂ • dramatic decrease in ductal branching morphogenesis as measured by numbers of branch tips is observed in mutants

increased prostate gland weight ( J:82767 )

♂ • modest but significant increase in prostate gland weight in mutants is seen

abnormal seminal vesicle morphology ( J:82767 )

♂ • adult seminal gland is elongated and tubular in contrast to wild-type glands which are curved with numerous lateral projections

abnormal seminal vesicle development ( J:82767 )

♂ • at birth, a lack of epithelial buds growing into surrounding mesenchyme is observed, but as mutants age, significant organ growth and epithelial folding does occur

abnormal seminal vesicle muscle layer morphology ( J:82767 )

♂ • smooth muscle sheath surrounding seminal vesicle is ~2-fold thicker and global smooth muscle distribution around vesicles is abnormal in mutants; muscle is organized into essentially smooth tube around seminal gland, usually not extending between folds of epithelium

reproductive system

abnormal prostate gland branching morphogenesis ( J:82767 )

♂ • branching morphogenesis is decreased compared to controls

decreased prostate gland duct number ( J:82767 )

♂ • dramatic decrease in ductal branching morphogenesis as measured by numbers of branch tips is observed in mutants

increased prostate gland weight ( J:82767 )

♂ • modest but significant increase in prostate gland weight in mutants is seen

abnormal seminal vesicle morphology ( J:82767 )

♂ • adult seminal gland is elongated and tubular in contrast to wild-type glands which are curved with numerous lateral projections

abnormal seminal vesicle development ( J:82767 )

♂ • at birth, a lack of epithelial buds growing into surrounding mesenchyme is observed, but as mutants age, significant organ growth and epithelial folding does occur

abnormal seminal vesicle muscle layer morphology ( J:82767 )

♂ • smooth muscle sheath surrounding seminal vesicle is ~2-fold thicker and global smooth muscle distribution around vesicles is abnormal in mutants; muscle is organized into essentially smooth tube around seminal gland, usually not extending between folds of epithelium

Genotype
MGI:3705020

ht3

• Allelic Composition: Fgfr2^tm1Dor/Fgfr2^svs
• Genetic Background: involves: 129X1/SvJ * CXB5/ByJ * FVB/N

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:119935 )

N • seminal vesicle defects seen in svs/svs mice are complemented by presence of functional Fgfr2 allele

Genotype
MGI:3705023

ht4

• Allelic Composition: Fgfr2^tm1.1Dor/Fgfr2^svs
• Genetic Background: involves: 129X1/SvJ * CXB5/ByJ * FVB/N

endocrine/exocrine glands

abnormal branching involved in seminal vesicle morphogenesis ( J:119935 )

♂ • at P5, seminal vesicles have not started branching morphogenesis

♂ • adult seminal vesicles lack all branching

reproductive system

abnormal branching involved in seminal vesicle morphogenesis ( J:119935 )

♂ • at P5, seminal vesicles have not started branching morphogenesis

♂ • adult seminal vesicles lack all branching