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Allele Symbol Allele Name Allele ID |
Aft abnormal feet and tail MGI:1856589 |
| Summary |
2 genotypes |
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
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• syndactyly of digits 3 and 4 of the hindfeet, 50% penetrance
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• 50% penetrance
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| ♀ | phenotype observed in females |
| ♂ | phenotype observed in males |
| N | normal phenotype |
Phenotypes of Aft mutation
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• partial syndactyly of digits 3 and 4 on the hindlimbs, commonly unilateral
• several mutants are seen in which digits other than 3 and 4 are fused
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• syndactyly is caused by the persistence of the skin web between the digits and not due to fused bony elements
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• tail kinks are most likely caused by varying degrees of cartilage overgrowth and fusion and a dysmorphogenesis of bony elements attached to the fusion site
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• incompletely penetrant progressive late-onset hair loss (around 6-8 months of age) that starts locally around the snout and back of ears
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• at around 6-8 months of age, when local hair loss begins, the fur appears clumpy and unkempt
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• skin shows focal areas of decreased hair follicle density with fibrous tracts, pigment incontinence and increased mast cells
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• late-onset (6-8 months of age) of skin lesions following hair loss that progress into bleeding ulcerations
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• fibrosis in the dermis
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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO) |
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last database update 04/23/2024 MGI 6.23 |
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