Phenotypes associated with this allele

• Allele Symbol: t^AE5
• Allele Name: t, Albert Einstein 5
• Allele ID: MGI:1856563
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	t^AE5/t^AE5	Not Specified	MGI:4461323
cx2	T/t^AE5	Not Specified	MGI:4461426

Genotype
MGI:4461323

hm1

• Allelic Composition: t^AE5/t^AE5
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality, incomplete penetrance ( J:83862 )

• high frequency of still-born young

postnatal lethality, incomplete penetrance ( J:83862 )

• a substantial number die within 48 hours

• most die before weaning

early reproductive senescence ( J:83862 )

limbs/digits/tail

abnormal tail morphology ( J:83862 )

short tail ( J:83862 )

growth/size/body

decreased body size ( J:83862 )

decreased body weight ( J:83862 )

• mice that survive to weaning weigh 8 grams compared with the 15-20 gram weight of controls

reproductive system

early reproductive senescence ( J:83862 )

abnormal spermatogenesis ( J:83862 )

♂ • only 3 % to 23% of seminiferous tubules in mutant mice contain spermatozoa compared with 51-62% in normal males

arrest of spermiogenesis ( J:83862 )

♂ • even when present in normal numbers spermatids frequently failed to differentiate contributing to loss of fertility

reduced fertility ( J:83862 )

decreased litter size ( J:83862 )

• matings of homozygous mice produce half the number of expected young

immune system

abnormal thymus morphology ( J:83862 )

abnormal thymus cortex morphology ( J:83862 )

• histological analyses show disintegration of lymphocytes in both female and male neonates however the thymus of mice 1 to 4 months of age are normal

thymus cortex hypoplasia ( J:83862 )

• after 6 months of age the cortex region is smaller and totally absent in some mice

increased mast cell number ( J:83862 )

• after 6 months of age the incidence of mast cells in the spleen increases and the population becomes larger than seen on control mice

abnormal spleen morphology ( J:83862 )

• noticeable in histological analyses after 2 months of age

decreased spleen white pulp amount ( J:83862 )

• seen after 2 months of age along with a decline in activation

increased susceptibility to infection ( J:83862 )

hematopoietic system

abnormal thymus morphology ( J:83862 )

abnormal thymus cortex morphology ( J:83862 )

• histological analyses show disintegration of lymphocytes in both female and male neonates however the thymus of mice 1 to 4 months of age are normal

thymus cortex hypoplasia ( J:83862 )

• after 6 months of age the cortex region is smaller and totally absent in some mice

increased megakaryocyte cell number ( J:83862 )

• seen in the spleen after 2 months of age

increased mast cell number ( J:83862 )

• after 6 months of age the incidence of mast cells in the spleen increases and the population becomes larger than seen on control mice

abnormal spleen morphology ( J:83862 )

• noticeable in histological analyses after 2 months of age

decreased spleen white pulp amount ( J:83862 )

• seen after 2 months of age along with a decline in activation

endocrine/exocrine glands

abnormal thymus morphology ( J:83862 )

abnormal thymus cortex morphology ( J:83862 )

• histological analyses show disintegration of lymphocytes in both female and male neonates however the thymus of mice 1 to 4 months of age are normal

thymus cortex hypoplasia ( J:83862 )

• after 6 months of age the cortex region is smaller and totally absent in some mice

Genotype
MGI:4461426

cx2

• Allelic Composition: T/t^AE5
• Genetic Background: Not Specified

limbs/digits/tail

abnormal tail morphology ( J:83862 )

absent tail ( J:83862 )