Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkiqk-v mutation
(2 available);
any
Qki mutation
(26 available)
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Brain morphology in Qkie5/Qkie5 and Qkiqk-v/Qkiqk-v mice
hearing/vestibular/ear
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• prolonged latency for all peaks and larger amplitudes for P1/N1
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nervous system
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• onset of seizures begins at 6-8 weeks of age; seizures occur less frequently than in homozygous Qke5 mice
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• aging mutants exhibit Purkinje cell axonal swellings, indicating neurodegeneration
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• decrease in myelination, however more axons are surrounded by thin myelin sheaths than seen in Qke5 homozygotes
(J:102038)
• microsomes prepared from brains of 18 day old homozygotes show a reduction in fatty acid chain elongation activity with arachidoyl CoA, behenoyl CoA, and palmitoyl CoA substrates
(J:160743)
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behavior/neurological
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• onset of seizures begins at 6-8 weeks of age; seizures occur less frequently than in homozygous Qke5 mice
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reproductive system
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• the testis contain many spermatogenic cells, but few spermatozoa and the spermatozoa collected from the cauda epididymis all have abnormal heads and/or tails and less than 0.5% are barely motile, and although in vitro fertilization is not successful, intracytoplasmic sperm injection and round spermatid injection are successful in production of offspring from homozygous males
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cellular
Allelic
Composition |
Qkiqk-v/Qkiqk-v
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Genetic
Background |
involves: C3H/Di * DBA/2J |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkiqk-v mutation
(2 available);
any
Qki mutation
(26 available)
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nervous system
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• following swimming, some mice become motionless and then display a tonic extension of hindlimbs for several minutes
• some mice exhibit adduction of limbs under a flexed trunk and then become stiff and motionless for several seconds
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• region from olfactory bulb to sacral spinal cord is deficient in myelin at all ages studied (12 days to 4 months)
• loss of myelination begins at the junction of peripheral and central nervous systems
• cranial and spinal nerves (except optic nerve) are myelinated
• some fragments of myelin are seen in almost all fiber tracts
• cells in white matter and grey matter tracts appear normal
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behavior/neurological
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• tremors are most evident in the caudal part of the trunk and proximal portions of hind extremities
• visually, the rate of tremors are 2 to 3 per second
• tremors are first observed at 10-12 days of age and reach full expression by 3 weeks
• in some animals, tremors diminish at 3 months
• physical contact with the mouse reduces or stops tremors
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• some animals exhibit hindlimb weakness at 3 months of age
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• following swimming, some mice become motionless and then display a tonic extension of hindlimbs for several minutes
• some mice exhibit adduction of limbs under a flexed trunk and then become stiff and motionless for several seconds
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reproductive system
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• male homozygotes rarely sire offspring
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkiqk-v mutation
(2 available);
any
Qki mutation
(26 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkiqk-v mutation
(2 available);
any
Qki mutation
(26 available)
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behavior/neurological
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• decrease in the frequency of exploratory sniffing (at wire mesh or a novel object) and leans against the novel object in males
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• increase in the frequency of hair fluffing in males
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• decrease in the frequency of leaning against the wall or a novel object and single forepaw lifts in males
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• decrease in the frequency of wire mesh climbing in males
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• walk slowly with a trembling gait
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Qkiqk-v mutation
(2 available);
any
Qki mutation
(26 available)
Tg(PGK2-Pacrg)#Jus mutation
(0 available)
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reproductive system
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N |
• all males are fertile and sire a normal number of litters
• average litter size is similar to wild type controls
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• sperm titers are reduced about 30% relative to wild type controls but are considerably higher than in the absence of the transgene
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cellular
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• sperm titers are reduced about 30% relative to wild type controls but are considerably higher than in the absence of the transgene
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Allelic
Composition |
Del(17)TOrl/+
Qkiqk-v/Qki+
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Genetic
Background |
involves: C57BL/6J * Orl:Swiss |
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behavior/neurological
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• mice heterozygous for T and Qk display tremors characteristic of the recessive mutation QK, demonstrating that T comprises a deletion
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limbs/digits/tail
Analysis Tools