Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation
(1 available);
any
Dmd mutation
(153 available)
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nervous system
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• mice exhibit an alteration in Muller cell current profile such that the current is weakest in the end feet with a gradual increase moving up the proximal process unlike in wild-type cells
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vision/eye
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• mice exhibit an alteration in Muller cell current profile such that the current is weakest in the end feet with a gradual increase moving up the proximal process unlike in wild-type cells
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation
(1 available);
any
Dmd mutation
(153 available)
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mortality/aging
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• fewer than expected mice survive until weaning compared to Dmdmdx mice
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reproductive system
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• fewer than exected mice are produced compared to Dmdmdx mice
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muscle
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• in mutant mice, myofibers contain fibers of different diameters with centrally located nuclei
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• 70% of myofibers contain central nuclei unlike in wild-type mice
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• mutant mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm with increased severity upon aging
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• mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm unlike in wild-type mice that increases with age
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muscle
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• authors state that mice develop the same skeletal muscle abnormalities as observed in Dmdmdx Utrntm1Ked mice
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nervous system
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N |
• unlike in Dmdmdx Utrntm1Ked mice, brain morphology is normal
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respiratory system
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N |
• unlike in Dmdmdx Utrntm1Ked mice, lung morphology is normal
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liver/biliary system
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N |
• liver morphology is normal
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renal/urinary system
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N |
• kidney morphology is normal
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reproductive system
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N |
• ovary morphology is normal
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muscle
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• authors state that mice develop the same skeletal muscle abnormalities as observed in Dmdmdx Utrntm1Ked mice
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nervous system
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N |
• unlike in Dmdmdx Utrntm1Ked mice, brain morphology is normal
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respiratory system
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N |
• unlike in Dmdmdx Utrntm1Ked mice, lung morphology is normal
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liver/biliary system
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N |
• liver morphology is normal
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renal/urinary system
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N |
• kidney morphology is normal
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reproductive system
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N |
• testis morphology is normal
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation
(1 available);
any
Dmd mutation
(153 available)
|
|
|
muscle
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• skeletal muscles exhibit variation in fiber size and centrally located nuclei unlike in wild-type mice
• mice exhibit macrophage invasion into muscles unlike in wild-type mice
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• highest specific tetanic force is lower than in wild-type mice
• at high frequencies mice titanic force is greater than in Dmdmdx-4Cv mice
• following eccentric contraction damage, force is reduced to unlike in wild-type mice that experience only a moderate drop in force but not as severely as in Dmdmdx-4Cv mice
• age exacerbates force losses
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vision/eye
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N |
• retina morphology is normal
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• mice exhibit an alteration in Muller cell current profile such that the current is weakest in the end feet with a gradual increase moving up the proximal process unlike in wild-type cells
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• mice exhibit a severely attenuated b-wave amplitude compared to wild-type mice
• b-wave and OP3 wave implicit times are delayed compared to in wild-type mice
• derived positive (P2) responses are delayed compared to in wild-type mice
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behavior/neurological
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• mice exhibit stronger grip strength than Dmdmdx-4Cv mice
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nervous system
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• mice exhibit an alteration in Muller cell current profile such that the current is weakest in the end feet with a gradual increase moving up the proximal process unlike in wild-type cells
|
|
|
| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation
(1 available);
any
Dmd mutation
(153 available)
|
|
|
mortality/aging
|
|
• fewer than expected mice survive until weaning compared to Dmdmdx mice
|
reproductive system
|
|
• fewer than exected mice are produced compared to Dmdmdx mice
|
muscle
|
|
• in mutant mice, myofibers contain fibers of different diameters with centrally located nuclei
|
|
|
• 70% of myofibers contain central nuclei unlike in wild-type mice
|
|
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• mutant mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm with increased severity upon aging
|
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• mice exhibit fibrosis, fatty infiltration and necrosis in the diaphragm unlike in wild-type mice that increases with age
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Allelic
Composition |
Dmdmdx-3Cv/Y
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Genetic
Background |
involves: C3H/HeHa * C57BL/6Ros * C57BL/10Sn * M. m. castaneus * M. m. musculus |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Dmdmdx-3Cv mutation
(1 available);
any
Dmd mutation
(153 available)
|
|
|
muscle
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• mice exhibit skeletal muscle fiber degeneration
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• electromyograms reveal peudomyotonia unlike in wild-type mice
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cardiovascular system
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• unlike wild-type, some cardiac fibrosis is observed
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vision/eye
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• although the a-wave amplitude is normal, the b-wave is attenuated by more than 50%
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Analysis Tools