Phenotypes associated with this allele

• Allele Symbol: Gli3^Xt-3H
• Allele Name: extra toes 3 Harwell
• Allele ID: MGI:1856284
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Gli3^Xt-3H/Gli3^Xt-3H	involves: 101/H * C3H/HeH	MGI:3784699
ht2	Gli3^Xt-3H/Gli3^+	involves: 101/H * C3H/HeH	MGI:3784698

Genotype
MGI:3784699

hm1

• Allelic Composition: Gli3^Xt-3H/Gli3^Xt-3H
• Genetic Background: involves: 101/H * C3H/HeH

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

prenatal lethality ( J:64111 )

limbs/digits/tail

abnormal digit morphology ( J:5053 )

• effects of mutation are similar to those observed in Gli3^Xt homozygotes but show greater severity

brachyphalangia ( J:64111 )

• displayed on all feet

polydactyly ( J:64111 )

• high-grade polydactyly is observed

skeleton

brachyphalangia ( J:64111 )

• displayed on all feet

nervous system

exencephaly ( J:5123 )

• frequently observed

craniofacial

bilateral cleft upper lip ( J:5123 )

• unilateral or bilateral harelip is present in some fetuses from 16 days onward

unilateral cleft upper lip ( J:5123 )

• unilateral or bilateral harelip is present in some fetuses from 16 days onward

homeostasis/metabolism

edema ( J:5123 )

• more pronounced than in Gli3^Xthomozygotes

integument

bleb ( J:5123 )

• blebs are often present on lower jaw, under the upper lip, in the external auditory meatus, on the cornea, on the back of the head and between the digits of the feet

growth/size/body

bilateral cleft upper lip ( J:5123 )

• unilateral or bilateral harelip is present in some fetuses from 16 days onward

unilateral cleft upper lip ( J:5123 )

• unilateral or bilateral harelip is present in some fetuses from 16 days onward

Genotype
MGI:3784698

ht2

• Allelic Composition: Gli3^Xt-3H/Gli3⁺
• Genetic Background: involves: 101/H * C3H/HeH

limbs/digits/tail

abnormal digit morphology ( J:5053 , J:5123 )

• preaxial digits of fore-feet are more markedly shortened than in Gli3^Xt heterozygotes (J:5053)

• in some animals, hind-feet may show a double claw malformation (J:5053)

• forefoot has a nubbin at base of digit V; in extreme cases, digit II may be flexed (J:5123)

• pollex is broadened (J:5123)

abnormal hallux morphology ( J:5053 , J:5123 )

• hind-feet display a shortening and thickening of the hallux, rather than having a separate extra digital rudiment (J:5053)

• hallux of hind-feet is thick and carries a broad claw (J:5123)

• hallux may be grooved longitudinally (J:5123)

brachyphalangia ( J:5053 )

• preaxial digits of fore-feet are more markedly shortened than in Gli3^Xt heterozygotes

syndactyly ( J:5123 )

• in some familial lines of mutants, soft tissue syndactylism between digits II, III, and IV of hind-foot and digits III and IV of fore-foot is regularly observed

polysyndactyly ( J:5053 )

• in some animals, hind-feet may show syndactylous extra phalanges

skeleton

abnormal interfrontal bone morphology ( J:5123 )

• interfrontal bone is present with greater frequency than in wild-type littermates

brachyphalangia ( J:5053 )

• preaxial digits of fore-feet are more markedly shortened than in Gli3^Xt heterozygotes

abnormal sternum morphology ( J:5123 )

• sternum is usually affected with individual sternebrae being indistinguishable in some cases; sternum is shortened and thickened

sternebra fusion ( J:5123 )

• in some animals, sternebral fusions are observed

short sternum ( J:5123 )

• sternum is shortened

craniofacial

abnormal interfrontal bone morphology ( J:5123 )

• interfrontal bone is present with greater frequency than in wild-type littermates

abnormal facial morphology ( J:5123 )

• some fetuses have a transitional facial bleb confined to the 13-day embryonic stage

pigmentation

belly spot ( J:5123 )

• Background Sensitivity: a belly spot may be seen depending on genetic background

integument

belly spot ( J:5123 )

• Background Sensitivity: a belly spot may be seen depending on genetic background

growth/size/body

abnormal facial morphology ( J:5123 )

• some fetuses have a transitional facial bleb confined to the 13-day embryonic stage