Phenotypes associated with this allele

• Allele Symbol: Foxn1^nu-str
• Allele Name: nude streaker
• Allele ID: MGI:1856109
• Summary: 1 genotype

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Foxn1^nu-str/Foxn1^nu-str	AKR/J-Foxn1^nu-str/J	MGI:2451260

Genotype
MGI:2451260

hm1

• Allelic Composition: Foxn1^nu-str/Foxn1^nu-str
• Genetic Background: AKR/J-Foxn1^nu-str/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:30715 )

• reduced life span due to susceptibility to infection (ave. 236 days)

growth/size/body

cachexia ( J:30715 )

• "wasting disease"

immune system

abnormal immune system morphology ( J:24755 )

abnormal immune system cell morphology ( J:30715 )

increased granulocyte number ( J:30715 )

increased eosinophil cell number ( J:30715 )

• slightly

increased neutrophil cell number ( J:30715 )

decreased lymphocyte cell number ( J:30715 )

• peripheral lymphocytes reduced to about 44.2% of white cells as opposed to 78% in controls

decreased T cell number ( J:30715 )

• reduced proliferative response to T-cell mitogens

abnormal immune system organ morphology ( J:30715 )

athymia ( J:24755 )

spleen hypoplasia ( J:30715 )

• periarteriolar regions of spleen severely depleted

abnormal Peyer's patch morphology ( J:30715 )

• tissue between primary nodules severely depleted

abnormal Peyer's patch germinal center morphology ( J:30715 )

• lack well developed germinal centers

lymph node hypoplasia ( J:30715 )

• deep cortical areas of lymph nodes are severely depleted

abnormal immune system physiology ( J:30715 )

abnormal humoral immune response ( J:30715 )

• decreased humoral response to thymus dependent antigens

• 20 fold reduction in IgM plaque forming response to sheep erythrocytes

decreased immunoglobulin level ( J:30715 )

• decreased serum Ig levels

increased length of allograft survival ( J:30715 )

neoplasm

decreased incidence of tumors by chemical induction ( J:43880 )

• no chemically induced carcinogenesis observed in two stage protocols using DMBA and TPA

decreased lymphoma incidence ( J:30715 )

• refractory to thymic lymphoma

increased sarcoma incidence ( J:30715 )

• lymphoreticular neoplasms observed (reticulum cell sarcoma)

hematopoietic system

athymia ( J:24755 )

increased granulocyte number ( J:30715 )

increased eosinophil cell number ( J:30715 )

• slightly

increased neutrophil cell number ( J:30715 )

decreased lymphocyte cell number ( J:30715 )

• peripheral lymphocytes reduced to about 44.2% of white cells as opposed to 78% in controls

decreased T cell number ( J:30715 )

• reduced proliferative response to T-cell mitogens

spleen hypoplasia ( J:30715 )

• periarteriolar regions of spleen severely depleted

decreased immunoglobulin level ( J:30715 )

• decreased serum Ig levels

integument

hairless ( J:24755 )

homeostasis/metabolism

decreased incidence of tumors by chemical induction ( J:43880 )

• no chemically induced carcinogenesis observed in two stage protocols using DMBA and TPA

endocrine/exocrine glands

athymia ( J:24755 )