All Phenotypes Mitf<mi-ew> MGI Mouse

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Phenotypes associated with this allele

Allele Symbol
Allele Name
Allele ID

Mitf^mi-ew
eyeless white
MGI:1856094

Summary

4 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Mitf^mi-ew/Mitf^mi-ew	involves: C57BL/6Bn * NAW	MGI:4455020
ht2	Mitf^mi-ew/Mitf^tm1Arnh	involves: 129S1/Sv * C57BL/6 * NAW	MGI:3774179
cx3	Mitf^mi-ew/Mitf^mi-ew Tfe3^tm1Est/Tfe3^tm1Est	either: (involves: 129/Sv * 129S1/Sv * C57BL/6Bn * NAW) or (involves: 129S1/Sv * C57BL/6Bn * C57BL/6J * NAW)	MGI:3044416
cx4	Mitf^mi-ew/Mitf^mi-ew Tfe3^tm1Est/Tfe3⁺	either: (involves: 129/Sv * 129S1/Sv * C57BL/6Bn * NAW) or (involves: 129S1/Sv * C57BL/6Bn * C57BL/6J * NAW)	MGI:4455029

Allelic Composition	Mitf^mi-ew/Mitf^mi-ew
Genetic Background	involves: C57BL/6Bn * NAW

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-ew mutation (1 available); any Mitf mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

skeleton

exostosis ( J:89821 )

• 3 week old bones show signs of hyperostosis, with extensions of bony trabeculae that reach further into the bone marrow cavity than in wild-type mice

osteopetrosis ( J:89821 )

• mild osteopetrosis

vision/eye

microphthalmia ( J:89821 )

• severely microphthalmic

integument

absent coat pigmentation ( J:89821 )

• white coat

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Camurati-Engelmann disease		DOID:4997	OMIM:131300 OMIM:606631	J:89821

Allelic Composition	Mitf^mi-ew/Mitf^tm1Arnh
Genetic Background	involves: 129S1/Sv * C57BL/6 * NAW

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-ew mutation (1 available); any Mitf mutation (72 available)
Mitf^tm1Arnh mutation (0 available); any Mitf mutation (72 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:130168 )

• mice have a white coat color rarely with some dark spots

vision/eye

vision/eye phenotype ( J:130168 )

N	• mice have normal size eyes unlike the small eyes in mice with homozygous null alleles of this gene

integument

absent coat pigmentation ( J:130168 )

• mice have a white coat color rarely with some dark spots

Allelic Composition	Mitf^mi-ew/Mitf^mi-ew Tfe3^tm1Est/Tfe3^tm1Est
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL/6Bn * NAW) or (involves: 129S1/Sv * C57BL/6Bn * C57BL/6J * NAW)

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Mitf^mi-ew mutation (1 available); any Mitf mutation (72 available)
Tfe3^tm1Est mutation (1 available); any Tfe3 mutation (21 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:89821 )

• mice die within 3 weeks of birth

pigmentation

absent coat pigmentation ( J:89821 )

• mice have a white coat; similar to Mitf^mi-ew/mi-ew mice

craniofacial

delayed tooth eruption ( J:89821 )

growth/size/body

delayed tooth eruption ( J:89821 )

decreased body weight ( J:89821 )

skeleton

delayed tooth eruption ( J:89821 )

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

osteopetrosis ( J:89821 )

• severe

vision/eye

microphthalmia ( J:89821 )

• similar to Mitf^mi-ew/mi-ew mice

hematopoietic system

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

immune system

abnormal osteoclast morphology ( J:89821 )

• small osteoclasts

integument

absent coat pigmentation ( J:89821 )

• mice have a white coat; similar to Mitf^mi-ew/mi-ew mice

Allelic Composition	Mitf^mi-ew/Mitf^mi-ew Tfe3^tm1Est/Tfe3⁺
Genetic Background	either: (involves: 129/Sv * 129S1/Sv * C57BL/6Bn * NAW) or (involves: 129S1/Sv * C57BL/6Bn * C57BL/6J * NAW)

Find Mice

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

pigmentation

absent coat pigmentation ( J:89821 )

• white coat

skeleton

osteopetrosis ( J:89821 )

• osteopetrosis is more severe than in Mitf^mi-ew homozygotes but less severe than in double homozygotes

vision/eye

microphthalmia ( J:89821 )

integument

absent coat pigmentation ( J:89821 )

• white coat

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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