About   Help   FAQ
Phenotypes associated with this allele
Allele Symbol
Allele Name
Allele ID 		Ap3d1mh-2J
mocha 2 Jackson
MGI:1856084
Summary 5 genotypes
Jump to Allelic Composition Genetic Background Genotype ID
hm1
 		Ap3d1mh-2J/Ap3d1mh-2J C3H/HeJ-Ap3d1mh-2J/J MGI:3765906
hm2
 		Ap3d1mh-2J/Ap3d1mh-2J involves: C3H/HeJ MGI:3765905
hm3
 		Ap3d1mh-2J/Ap3d1mh-2J involves: C3H/HeJ * C57BL/6J MGI:3765907
hm4
 		Ap3d1mh-2J/Ap3d1mh-2J involves: C3H/HeJ * C57BL/6J * CAST/Ei MGI:3794660
cx5
 		Ap3d1mh-2J/Ap3d1mh-2J
Nxf1Mvb1/Nxf1Mvb1 		involves: C3H/HeJ * C57BL/6 MGI:3848524


Genotype
MGI:3765906
hm1
Allelic
Composition		 Ap3d1mh-2J/Ap3d1mh-2J
Genetic
Background		 C3H/HeJ-Ap3d1mh-2J/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap3d1mh-2J mutation (1 available); any Ap3d1 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
pigmentation
diluted coat color ( J:82264 )
• the degree of dilution is less severe than in mocha homozygotes

integument
diluted coat color ( J:82264 )
• the degree of dilution is less severe than in mocha homozygotes




Genotype
MGI:3765905
hm2
Allelic
Composition		 Ap3d1mh-2J/Ap3d1mh-2J
Genetic
Background		 involves: C3H/HeJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap3d1mh-2J mutation (1 available); any Ap3d1 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
nervous system phenotype ( J:96307 )
N
• mocha 2 Jackson homozygotes do not display the hypersynchronized EEG or head tilt seen in mocha homozygotes




Genotype
MGI:3765907
hm3
Allelic
Composition		 Ap3d1mh-2J/Ap3d1mh-2J
Genetic
Background		 involves: C3H/HeJ * C57BL/6J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap3d1mh-2J mutation (1 available); any Ap3d1 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
hearing/vestibular/ear phenotype ( J:82264 )
N
• hearing is normal, even up to ages 1.5 years, with ABR readings normal at frequencies of 4,000, 10,000, and 20,000

behavior/neurological
hyperactivity ( J:82264 )
• at least as severe as that seen in mocha homozygotes




Genotype
MGI:3794660
hm4
Allelic
Composition		 Ap3d1mh-2J/Ap3d1mh-2J
Genetic
Background		 involves: C3H/HeJ * C57BL/6J * CAST/Ei
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap3d1mh-2J mutation (1 available); any Ap3d1 mutation (79 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hearing/vestibular/ear
abnormal auditory brainstem response ( J:59842 )
• The S1 response, but not the S2 response, is greater than in controls and the resulting auditory gating has a trend toward enhanced gating relative to controls but it does not reach statistical significance in this study
• this phenotype is less severe in the mh-2J homozygotes than in mh homozygotes

behavior/neurological
abnormal spike wave discharge ( J:59842 )
• spike discharge episodes of .25-1 mV amplitude and approximately 0.5-2 seconds duration observed for 4 of 7 homozygotes, less frequently than in mocha homozygotes

nervous system
abnormal spike wave discharge ( J:59842 )
• spike discharge episodes of .25-1 mV amplitude and approximately 0.5-2 seconds duration observed for 4 of 7 homozygotes, less frequently than in mocha homozygotes




Genotype
MGI:3848524
cx5
Allelic
Composition		 Ap3d1mh-2J/Ap3d1mh-2J
Nxf1Mvb1/Nxf1Mvb1
Genetic
Background		 involves: C3H/HeJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ap3d1mh-2J mutation (1 available); any Ap3d1 mutation (79 available)
Nxf1Mvb1 mutation (1 available); any Nxf1 mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype

Ap3d1mh-2J/Ap3d1mh-2J coat color dilution is attenuated in Ap3d1mh-2J/Ap3d1mh-2J Nxf1Mvb1/Nxf1Mvb1 mice

pigmentation
abnormal coat/hair pigmentation ( J:149430 )
• normalization of pigmentation relative to Ap3d1mh-2J single homozygotes

behavior/neurological
tremors ( J:149430 )
• reduced tremors relative to Ap3d1mh-2J single homozygotes

integument
abnormal coat/hair pigmentation ( J:149430 )
• normalization of pigmentation relative to Ap3d1mh-2J single homozygotes




Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/14/2024
MGI 6.23 		The Jackson Laboratory