Phenotypes associated with this allele

• Allele Symbol: Axin1^Fu-kb
• Allele Name: knobbly
• Allele ID: MGI:1856037
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Axin1^Fu-kb/Axin1^Fu-kb	Not Specified	MGI:3663630
ht2	Axin1^Fu-kb/Axin1^+	Not Specified	MGI:3835024

Genotype
MGI:3663630

hm1

• Allelic Composition: Axin1^Fu-kb/Axin1^Fu-kb
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality, complete penetrance ( J:13850 )

• retarded and malformed embryos die by E9.5

embryo

abnormal developmental patterning ( J:13850 )

• high frequency of twinning; twins are usually in separate yolk sacs and combinations of normal-normal, normal-mutant, and mutant-mutant are found

abnormal ectoderm development ( J:13850 )

• exhibit a defect in the ectoderm at E7.25, with the appearance of rounded, crowded, granular cells in the region anterior to the primitive streak and by E8, the lesion has spread along the ectoderm and contains many dead and dying cells

• ectoderm is uneven in thickness throughout the -circumference

small amniotic cavity ( J:13850 )

• amniotic cavity fails to elongate properly

reproductive system

impaired spacing of implantation sites ( J:13850 )

♀

twin decidual capsule ( J:13850 )

♀ • twins are usually in separate yolk sacs in combinations of normal-normal, normal-mutant and mutamt-mutant

Genotype
MGI:3835024

ht2

• Allelic Composition: Axin1^Fu-kb/Axin1⁺
• Genetic Background: Not Specified

limbs/digits/tail

kinked tail ( J:13701 )