Axin1^Fu-kb
Spontaneous Allele Detail

Summary

• Symbol: Axin1^Fu-kb
• Name: axin 1; knobbly
• MGI ID: MGI:1856037
• Synonyms: Kb
• Gene: Axin1 Location: Chr17:26357662-26414785 bp, + strand Genetic Position: Chr17, 13.07 cM
• Alliance: Axin1^Fu-kb page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• The mutation is an IAP retrotransposon insertion into exon 7 of the gene. (J:43298)
• Inheritance: Semidominant

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Axin1 Mutation: 44 strains or lines available

Notes

The knobbly mutation was found in a mutagenesis experiment at Harwell, England. Heterozygotes have short, bent tails. They occur in less than the expected proportion in offspring of male but not of female heterozygotes, suggesting either reduced penetrance or a low transmission ratio. Axin1^Fu-kb homozygotes closely resemble Axin1^Fu-ki homozygotes and die by embryonic day 9 (J:7449). The knobbly mutation is allelic to kinky, and thus to fused (J:13850).

References

• Original: J:13701 Lyon MF, et al., Low is a t-haplotype. Mouse News Lett. 1977;56:37
• All: 4 reference(s)