Phenotypes associated with this allele

• Allele Symbol: Frl^b
• Allele Name: furloss b
• Allele ID: MGI:1856033
• Summary: 2 genotypes

Jump to	Allelic Composition	Genetic Background	Genotype ID
hm1	Frl^b/Frl^b	Not Specified	MGI:4361516
ht2	Frl^b/Frl^+	Not Specified	MGI:4361514

Genotype
MGI:4361516

hm1

• Allelic Composition: Frl^b/Frl^b
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

decreased survivor rate ( J:7103 )

• significantly fewer homozygotes than expected are recovered from heterozygous matings but those recovered are fertile

prenatal lethality, incomplete penetrance ( J:7103 )

• losses are not seen after birth

integument

abnormal coat appearance ( J:7103 )

• identical in appearance to heterozygotes

abnormal hair growth ( J:7103 )

Genotype
MGI:4361514

ht2

• Allelic Composition: Frl^b/Frl⁺
• Genetic Background: Not Specified

growth/size/body

decreased birth body size ( J:7103 )

• affected mice are normal in size until about 16 days of age when they appear smaller than normal littermates

decreased body weight ( J:7103 )

• weanlings weigh 3 percent less than wild-type littermates

integument

focal hair loss ( J:7103 )

• Background Sensitivity: random hair loss in patches occurs on the forehead, then back and abdomen

progressive hair loss ( J:7103 )

• after the final shedding cycle there is increasing hair loss until 12-14 weeks of age when affected mice are completely bare except for the muzzle

sparse hair ( J:7103 )

• typical at 40 days of age

striated fur ( J:7103 )

• Background Sensitivity: on this background affected mice have a slight coat striation compared with normal littermates by 7 days of age; on BALB/c (N7) this feature is distinguishable by 10 days of age

abnormal hair shedding ( J:7103 )

• patchy loss of the first coat is followed by regrowth during days 16-20, followed by second patchy shedding one week later

• final shedding cycle begins soon after 40 days of age, first on the forehead and spreads over the back and abdomen

wrinkled skin ( J:7103 )

• Background Sensitivity: on this background by 7 days of age wrinkled skin differentiates affected mice from normal littermates; on BALB/c (N7) affected mice are distinguishable from normal littermates by 10 days of age