Phenotypes associated with this allele
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation
(4 available);
any
Tyrp1 mutation
(162 available)
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation
(4 available);
any
Tyrp1 mutation
(162 available)
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pigmentation
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• hair tips are brown, the rest of the hair shaft white
• mice are distinguished from normal by 2 weeks of age
• coat color is rapidly lightened as hair lengthens
• moulting often creates a mosaic coat color pattern
• the lighter coat color is difficult to see on an agouti background
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integument
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• hair tips are brown, the rest of the hair shaft white
• mice are distinguished from normal by 2 weeks of age
• coat color is rapidly lightened as hair lengthens
• moulting often creates a mosaic coat color pattern
• the lighter coat color is difficult to see on an agouti background
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation
(4 available);
any
Tyrp1 mutation
(162 available)
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Tyrp1B-lt/Tyrp1B-lt
pigmentation
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• iris pigmentation is dispersed
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vision/eye
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• iris pigmentation is dispersed
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation
(4 available);
any
Tyrp1 mutation
(162 available)
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hearing/vestibular/ear
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• pigmentation is abundant as clumps in older mice
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• loss of endocochlear potential correlates with loss of pigment
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• potential is reduced to 19-59mV in 30% of two age groups: 2.5 to 4 mo and 1-2 years
• loss of potential is correlated with loss of pigment with age
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pigmentation
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• pigmentation is abundant as clumps in older mice
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• pigment is lost as mice age
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• base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color
• pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production
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integument
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• pigment is lost as mice age
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• base of hairs become lighter as more pigment is lost with age, older mice are pale grey in color
• pigment loss is due to premature melanocyte death mediated by natural toxicity of pigment production
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Allelic
Composition |
Tyrp1B-lt/Tyrp1+
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Genetic
Background |
involves: C58 |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation
(4 available);
any
Tyrp1 mutation
(162 available)
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pigmentation
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• the majority of each hair from tip down is pigmented, the lower part is less pigmented appearing gray
• mice are lighter than wildtype nonagouti mice but darker than homozygotes
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integument
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• the majority of each hair from tip down is pigmented, the lower part is less pigmented appearing gray
• mice are lighter than wildtype nonagouti mice but darker than homozygotes
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Allelic
Composition |
Tyrp1B-lt/Tyrp1+
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Genetic
Background |
Not Specified |
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| Find Mice |
Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tyrp1B-lt mutation
(4 available);
any
Tyrp1 mutation
(162 available)
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hearing/vestibular/ear
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• potential is reduced in 30% of mice as mice age
• reduction in potential is correlated with appearance of abundant pigment clumps in the stria vascularis
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pigmentation
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• coat pigment is reduced with age
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integument
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• coat pigment is reduced with age
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pigmentation
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• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment
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integument
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• dark sepia in color
• unlike mice wildtype for pink-eye the hairs are pigmented from tip to base and do not have large clumps of pigment, but may have small clumps of pigment
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pigmentation
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• the ventral hairs are substantially less pigmented than those of the dorsum
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• although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found
• by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes
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• variation in the amount of pigmentation present in one hair shaft versus the next
• variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft
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• hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions
• decreased pigmentation in the hair shafts with age
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integument
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• the ventral hairs are substantially less pigmented than those of the dorsum
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• although in early stages of hair growth the granules are round and relatively uniform in size, in later stages they are larger, more variable in size, and some clumping is found
• by the 9th day of a new hair growth cycle some hair bulbs are devoid of pigmentation and by 14 days very few follicles have active melanocytes
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• variation in the amount of pigmentation present in one hair shaft versus the next
• variation in the size ans shape of pigment granules, with some instances of large masses of pigment in a particular hair shaft
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• hair shafts have large clumps of pigmented granules predominantly restricted to the medullary regions
• decreased pigmentation in the hair shafts with age
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Allelic
Composition |
a/a
Tyrp1B-lt/Tyrp1+
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Genetic
Background |
Not Specified |
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pigmentation
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• the ventral hairs are substantially less pigmented than those of the dorsum
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• large clumps of pigment are found in hair and vibrissae, but less frequently than in homozygotes
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• fewer pigment granules per septum in proceeding from tip to base of the hair, but more pigment granules than in homozygotes
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integument
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• the ventral hairs are substantially less pigmented than those of the dorsum
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• large clumps of pigment are found in hair and vibrissae, but less frequently than in homozygotes
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• fewer pigment granules per septum in proceeding from tip to base of the hair, but more pigment granules than in homozygotes
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pigmentation
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• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft
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integument
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• more dilute than mice heterozygous for light due to a further diminution in the eumelanic pigment, but there is no alteration in the yellow bands of the hair shaft
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Allelic
Composition |
Ay/a
Tyrp1B-lt/?
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Genetic
Background |
Not Specified |
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pigmentation
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• the light mutation does not seem to impact the yellow phenotype since the coat color of mice without the light mutation is the same yellow coat color as that found in mice carrying at least one copy of the light mutation
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integument
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• the light mutation does not seem to impact the yellow phenotype since the coat color of mice without the light mutation is the same yellow coat color as that found in mice carrying at least one copy of the light mutation
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hematopoietic system
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• the mild, erythropoietin-resistant, macrocytic anemia that results from defective mitosis in homozygous stem cells can only be resuced by bone marrow transplantation from wild-type donors if the homozygotes are first lethally irradiated
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cellular
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• 5% to 15% of mitotic figures obtained from a variety of homozygous tissues have abnormal mitotic figures
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growth/size/body
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• Background Sensitivity: homozygotes show modest microcephaly on a WBB6F1 background, but more severe on a C57BL/6J congenic background
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reproductive system
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• homozygous females fail to deliver pups, often dying as a result, and fail to respond normally to estrogen or relaxin
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neoplasm
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• on the WB/Re x C57BL/6J F1 hybrid background Hertwig anemia homozygotes have greatly increased incidence of histiocytic sarcomas, with associated myelopoiesis, compared with homozygotes on congenic WB/Re or C57BL/6J backgrounds or non-homozygous mice on the WB/Re x C57BL/6J F1 hybrid background
• average age of tumor presentation begins after 1 year of age with an overall incidence in the F1 population of 63.5%
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nervous system
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• Background Sensitivity: shortened forebrain does not extend fully over the superior colliculus of the midbrain, but this is less severe than on the B57BL/6J congenic background
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Analysis Tools
