Dpysl2^tm1.1Dvaa
Targeted Allele Detail

Summary

• Symbol: Dpysl2^tm1.1Dvaa
• Name: dihydropyrimidinase-like 2; targeted mutation, 1.1, Daan MF van Aalten
• MGI ID: MGI:8459982
• Synonyms: Crmp2^S517A
• Gene: Dpysl2 Location: Chr14:67040313-67148410 bp, - strand Genetic Position: Chr14, 34.6 cM
• Alliance: Dpysl2^tm1.1Dvaa page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:293119
• Parent Cell Line: ART B6 3.6 (ES Cell)
• Strain of Origin: C57BL/6NTac

Mutation description

• Allele Type: Targeted (Not Applicable)
• Mutations: Insertion, Nucleotide substitutions
• Mutation details:

  Serine codon 517 (AGT) in exon 13 was changed to alanine (p.S517A) and an FRT site flanked neomycin resistance gene cassette was inserted into intron 13. The neo cassette was removed through subsequent Flp-mediated recombination. In the encoded protein, the mutation blocks O-GlcNAcylation of the affected residue, which affects learning and short-term memory. (J:293119)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dpysl2 Mutation: 36 strains or lines available

References

• Original: J:293119 Muha V, et al., Loss of CRMP2 O-GlcNAcylation leads to reduced novel object recognition performance in mice. Open Biol. 2019 Nov 29;9(11):190192
• All: 1 reference(s)