2310015A10Rik^tm1.1Gho
Targeted Allele Detail

Summary

• Symbol: 2310015A10Rik^tm1.1Gho
• Name: RIKEN cDNA 2310015A10 gene; targeted mutation 1.1, Sankar Ghosh
• MGI ID: MGI:8421742
• Synonyms: lnc15^-
• Gene: 2310015A10Rik Location: Chr12:80167320-80179618 bp, - strand Genetic Position: Chr12, 36.46 cM
• Alliance: 2310015A10Rik^tm1.1Gho page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:391954
• Parent Cell Line: Other (see notes) (ES Cell)
• Strain of Origin: C57BL/6NTac-Tyr^tm1Arte A^tm1.1Arte/Tac

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details:

  Exon 3 was replaced with an FRT-flanked neomycin resistance cassette. The neomycin resistance cassette was removed via flp-mediated recombination. Northern blot confirmed loss of the dominant approximate 1.4-kb species. The deletion does not detectably alter neighboring genes, including 1300014J16Rik expression in T cells or colon. (J:391954)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any 2310015A10Rik Mutation: 0 strains or lines available

Notes

Generated in FL19 ES cells derived from TAC:11227 on a C57BL/6NTac-Tyr A/Tac background

References

• Original: J:391954 Yang-Fischer R, et al., An inflammatory bowel disease-linked lncRNA suppresses transcription factor T-BET expression in T cells to limit intestinal inflammation. Immunity. 2026 Aug 20
• All: 1 reference(s)