Atf4^em1.1Jchen
Endonuclease-mediated Allele Detail

Summary

• Symbol: Atf4^em1.1Jchen
• Name: activating transcription factor 4; endonuclease-mediated mutation 1.1, Ju Chen
• MGI ID: MGI:8401673
• Synonyms: Atf4^gKO(e2)
• Gene: Atf4 Location: Chr15:80139385-80141742 bp, + strand Genetic Position: Chr15, 37.85 cM
• Alliance: Atf4^em1.1Jchen page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details:

  CRISPR/Cas9-mediated recombination inserted loxP sites around exon 2. Cre mediated recombination deleted exon 2. A truncated version of the protein is detected in intestines from null mice. (J:379595)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Atf4 Mutation: 24 strains or lines available

References

• Original: J:379595 Zhang Z, et al., Transcriptional readthrough at Atf4 locus suppresses Rps19bp1 and impairs heart development. Cardiovasc Res. 2026 Feb 14;121(18):2909-2921
• All: 1 reference(s)