Akr1c13^em1Jjwo
Endonuclease-mediated Allele Detail

Summary

• Symbol: Akr1c13^em1Jjwo
• Name: aldo-keto reductase family 1, member C13; endonuclease-mediated mutation 1, Joshua J Woodward
• MGI ID: MGI:8395685
• Synonyms: RECON^-
• Gene: Akr1c13 Location: Chr13:4241167-4255601 bp, + strand Genetic Position: Chr13, 2.34 cM, cytoband A1
• Alliance: Akr1c13^em1Jjwo page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details:

  CRISPR/Cas9-mediated recombination resulted in a single G insertion in exon 6, leading to a frameshift mutation and a stop codon after residue 200, which truncates the protein prior to the active site and c-di-AMP binding site. (J:389353)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akr1c13 Mutation: 26 strains or lines available

References

• Original: J:389353 Stamm CE, et al., RECON gene disruption enhances host resistance to enable genome-wide evaluation of intracellular pathogen fitness during infection. mBio. 2024 Aug 14;15(8):e0133224
• All: 1 reference(s)