Kcnj13^em1Fvs
Endonuclease-mediated Allele Detail

Summary

• Symbol: Kcnj13^em1Fvs
• Name: potassium inwardly-rectifying channel, subfamily J, member 13; endonuclease-mediated mutation 1, Francisco V Sepulveda
• MGI ID: MGI:8348359
• Synonyms: Kir7.1^fl
• Gene: Kcnj13 Location: Chr1:87314085-87322451 bp, - strand Genetic Position: Chr1, 44.3 cM
• Alliance: Kcnj13^em1Fvs page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready)
• Mutation: Insertion
• Mutation details: In two separate steps a loxP site was inserted into intron 1 and a second loxP site into intron 2 using sgRNAs and ssODN templates with CRISPR/Cas9 technology, creating a conditional-ready allele with exon 2 floxed. (J:386568)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Kcnj13 Mutation: 24 strains or lines available

References

• Original: J:386568 Henao JC, et al., Role of the Choroid Plexus Kir7.1 Channel in the Regulation of Mouse Cerebrospinal Fluid K(+) Concentration. Acta Physiol (Oxf). 2025 Dec;241(12):e70129
• All: 1 reference(s)