Ssh2^em2Cya
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ssh2^em2Cya
• Name: slingshot protein phosphatase 2; endonuclease-mediated mutation 2, Cyagen Biosciences
• MGI ID: MGI:8278796
• Gene: Ssh2 Location: Chr11:77107113-77351046 bp, + strand Genetic Position: Chr11, 46.36 cM
• Alliance: Ssh2^em2Cya page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/Cas9 technology deleted exon 8. Western blot analysis of testicular lysates and immunohistochemistry of testes confirmed the absence of protein. (J:364886)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ssh2 Mutation: 61 strains or lines available

References

• Original: J:364886 Xu K, et al., The Slingshot phosphatase 2 is required for acrosome biogenesis during spermatogenesis in mice. Elife. 2023 Mar 21;12
• All: 1 reference(s)