Piezo1^{em1(flpo)Huhz}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Piezo1^{em1(flpo)Huhz}
• Name: piezo-type mechanosensitive ion channel component 1; endonucleas-mediated mutation 1, Hongzhen Hu
• MGI ID: MGI:8268628
• Synonyms: Piezo1^flpo
• Gene: Piezo1 Location: Chr8:123208437-123278068 bp, - strand Genetic Position: Chr8, 71.31 cM
• Alliance: Piezo1^{em1(flpo)Huhz} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Piezo1^{em1(flpo)Huhz} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Piezo1 (MGI:3603204)

• CRISPR/cas9-mediated recombination inserted a P2A-flpo cassette after exon 51. (J:375058)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Piezo1 (mouse) Summary of all recombinase alleles driven by Piezo1. Alliance mouse Piezo1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Piezo1 Mutation: 88 strains or lines available

References

• Original: J:375058 Xie Z, et al., Enteric neuronal Piezo1 maintains mechanical and immunological homeostasis by sensing force. Cell. 2025 May 1;188(9):2417-2432.e19
• All: 1 reference(s)