Sertm2^em1Jnch
Endonuclease-mediated Allele Detail

Summary

• Symbol: Sertm2^em1Jnch
• Name: serine rich and transmembrane domain containing 2; endonuclease-mediated mutation 1, Jun-An Chen
• MGI ID: MGI:8261512
• Gene: Sertm2 Location: ChrX:142936691-142949270 bp, + strand Genetic Position: ChrX, 65.23 cM
• Alliance: Sertm2^em1Jnch page
• IMPC: Sertm2 gene page

Mutation origin

• Strain of Origin: C57BL/6J
• Project Collection: IMPC

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR-targeting introduced a frameshift mutation. (J:365477)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Sertm2 Mutation: 1 strain or line available

References

• Original: J:365477 Hsu FY, et al., Sertm2 is a conserved micropeptide that promotes GDNF-mediated motor neuron subtype specification. EMBO Rep. 2025 Apr;26(8):2013-2043
• All: 1 reference(s)