Iqsec3^{tm1c(KOMP)Wtsi}
Targeted Allele Detail

Summary

• Symbol: Iqsec3^{tm1c(KOMP)Wtsi}
• Name: IQ motif and Sec7 domain 3; targeted mutation 1c, Wellcome Trust Sanger Institute
• MGI ID: MGI:8257180
• Synonyms: Iqsec3 floxed
• Gene: Iqsec3 Location: Chr6:121349892-121450637 bp, - strand Genetic Position: Chr6, 57.28 cM
• Alliance: Iqsec3^{tm1c(KOMP)Wtsi} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:373367
• Parent Cell Line: JM8.N4 (ES Cell)
• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: The L1L2_Bact_P cassette was inserted at position 121404984 of Chromosome 6 upstream of the critical exon 3 (Build GRCm39). The cassette is composed of an FRT site followed by lacZ sequence and a loxP site. This first loxP site is followed by a neomycin resistance gene under the control of the human beta-actin promoter, SV40 polyA, a second FRT site and a second loxP site. A third loxP site is inserted downstream of the targeted exon 3 at position 121405959. The critical exon 3 is thus flanked by loxP sites. Flp-mediated recombination removed the lacZ and neomycin resistance gene leaving exon 3 floxed. Further information on targeting strategies used for this and other IKMC alleles can be found at http://www.informatics.jax.org/mgihome/nomen/IKMC_schematics.shtml (J:373367)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Iqsec3 Mutation: 51 strains or lines available

References

• Original: J:373367 Kim D, et al., IQSEC3 Deletion Impairs Fear Memory Through Upregulation of Ribosomal S6K1 Signaling in the Hippocampus. Biol Psychiatry. 2022 May 1;91(9):821-831
• All: 1 reference(s)