Dio3^em1(cre)Df
Endonuclease-mediated Allele Detail

Summary

• Symbol: Dio3^em1(cre)Df
• Name: deiodinase, iodothyronine type III; endonuclease-mediated mutation , Douglas Forrest
• MGI ID: MGI:8255300
• Synonyms: Dio3^Cre
• Gene: Dio3 Location: Chr12:110245664-110247531 bp, + strand Genetic Position: Chr12, 60.56 cM, cytoband F1
• Alliance: Dio3^em1(cre)Df page

Mutation origin

• Strain of Origin: C57BL/6

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Dio3^em1(cre)Df expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Dio3 (MGI:1306782)

• Mutation details: CRISPR/cas9-mediated recombination removed the ERT2 sequence from Dio3^{tm1.1(cre/ERT2)Df} to create a non-inducible allele. (J:367671)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Dio3 (mouse) Summary of all recombinase alleles driven by Dio3. Alliance mouse Dio3 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Dio3 Mutation: 7 strains or lines available

References

• Original: J:367671 Liu Y, et al., Serotonergic and Chemosensory Brain Areas and Sensory Ganglia Expressing Type 3 Deiodinase Mapped With Dio3Cre drivers. Endocrinology. 2025 May 19;166(7)
• All: 1 reference(s)