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Dio3tm1.1(cre/ERT2)Df
Targeted Allele Detail
Summary
Symbol: Dio3tm1.1(cre/ERT2)Df
Name: deiodinase, iodothyronine type III; targeted mutation 1.1, Douglas Forrest
MGI ID: MGI:8255294
Synonyms: Dio3CreERt2
Gene: Dio3  Location: Chr12:110245664-110247531 bp, + strand  Genetic Position: Chr12, 60.56 cM, cytoband F1
Alliance: Dio3tm1.1(cre/ERT2)Df page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:367671
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  C57BL/6
Mutation
description
Allele Type:    Targeted (Inducible, Recombinase)
Mutation:    Insertion
 
Dio3tm1.1(cre/ERT2)Df expression driven by 1 gene
 
Mutation details: The coding sequence was replaced with a cre/ERT2 cassette and FRT flanked neo cassette via homologous recombination. Flp-mediated recombination removed the selection cassette. (J:367671)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Dio3 (mouse)
Summary of all recombinase alleles driven by Dio3.
 

Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dio3 Mutation:  7 strains or lines available
References
Original:  J:367671 Liu Y, et al., Serotonergic and Chemosensory Brain Areas and Sensory Ganglia Expressing Type 3 Deiodinase Mapped With Dio3Cre drivers. Endocrinology. 2025 May 19;166(7)
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/06/2026
MGI 6.24 		The Jackson Laboratory