Tal1^{tm1.1(cre/ERT2)Trij}
Targeted Allele Detail

Summary

• Symbol: Tal1^{tm1.1(cre/ERT2)Trij}
• Name: T cell acute lymphocytic leukemia 1; targeted mutation 1, Jason W Triplett
• MGI ID: MGI:8254778
• Synonyms: Tal1^CreERT2
• Gene: Tal1 Location: Chr4:114913623-114928952 bp, + strand Genetic Position: Chr4, 52.73 cM
• Alliance: Tal1^{tm1.1(cre/ERT2)Trij} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:369690
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Inducible, Recombinase)
• Mutation: Insertion
• Tal1^{tm1.1(cre/ERT2)Trij} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tal1 (MGI:98480)

• Mutation details: A 2A-cre/ERT2 cassette was inserted in place of the TGA stop codon and a floxed neo cassette was inserted in the preceding intron via homologous recombination. Recombinase mediated recombination removed the neo cassette. (J:369690)
• Inheritance: Not Specified

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tal1 (mouse) Summary of all recombinase alleles driven by Tal1. Alliance mouse Tal1 gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tal1 Mutation: 31 strains or lines available

Notes

Lentiviral gene trap injected into zygotes.

References

• Original: J:369690 Johnson KO, et al., Postsynaptic NMDA Receptor Expression Is Required for Visual Corticocollicular Projection Refinement in the Mouse Superior Colliculus. J Neurosci. 2023 Feb 22;43(8):1310-1320
• All: 1 reference(s)