Bsgem1(BSG)Dfl
Endonuclease-mediated Allele Detail
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Symbol: |
Bsgem1(BSG)Dfl |
Name: |
basigin; endonuclease-mediated mutation 1, Dongfang Liu |
MGI ID: |
MGI:8250889 |
Synonyms: |
hCD147KI, hCD147KI-NSG |
Gene: |
Bsg Location: Chr10:79540325-79547803 bp, + strand Genetic Position: Chr10, 39.72 cM
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Alliance: |
Bsgem1(BSG)Dfl page
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Allele Type: |
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Endonuclease-mediated (Humanized sequence, Inserted expressed sequence) |
Mutation: |
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Insertion
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Bsgem1(BSG)Dfl expresses
1 gene
Knock-in expresses:
Organism |
Expressed Gene |
Homolog in Mouse |
Note |
human |
BSG (682) |
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Mutation details: The human BSG (CD147) cDNA was targeted to exon 1 via CRISPR/Cas9 technology resulting in a fusion protein with the first 22 amino acids of mouse Bsg signal peptide and amino acids 23-385 of human BSG that is expressed from the mouse promoter. Immunohistochemistry confirmed expression of the human protein in all tissues assayed in heterozygotes, as well as in red blood cells in the lung.
(J:369237)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Bsg Mutation: |
16 strains or lines available
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Original: |
J:369237 Badeti S, et al., Development of a novel human CD147 knock-in NSG mouse model to test SARS-CoV-2 viral infection. Cell Biosci. 2022 Jun 11;12(1):88 |
All: |
1 reference(s) |
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