Tfap2c^em1(cre)Jane
Endonuclease-mediated Allele Detail

Summary

• Symbol: Tfap2c^em1(cre)Jane
• Name: transcription factor AP-2, gamma; endonuclease-mediated mutation 1, Stephen M Jane
• MGI ID: MGI:8249487
• Synonyms: Tfap2c^Cre
• Gene: Tfap2c Location: Chr2:172391513-172400542 bp, + strand Genetic Position: Chr2, 94.87 cM, cytoband H3-H4
• Alliance: Tfap2c^em1(cre)Jane page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Recombinase)
• Mutation: Insertion
• Tfap2c^em1(cre)Jane expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Tfap2c (MGI:106032)

• Mutation details: CRISPR-Cas9 genome editing technology was used to insert a cassette containing a self-cleaving porcine teschovirus-1 2A (P2A) peptide sequence and a Cre recombinase gene into the endogenous gene prior to the stop codon. (J:355461)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Tfap2c (mouse) Summary of all recombinase alleles driven by Tfap2c. Alliance mouse Tfap2c gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tfap2c Mutation: 26 strains or lines available

References

• Original: J:355461 Deng Z, et al., Single-cell transcriptomics reveals the cellular identity of a novel progenitor population crucial for murine neural tube closure. Heliyon. 2024 Sep 15;10(17):e37259
• All: 1 reference(s)