Fhl2^em1Huag
Endonuclease-mediated Allele Detail

Summary

• Symbol: Fhl2^em1Huag
• Name: four and a half LIM domains 2; endonuclease-mediated mutation 1, Guohua Hua
• MGI ID: MGI:8249201
• Synonyms: Fhl2 KO
• Gene: Fhl2 Location: Chr1:43162234-43236144 bp, - strand Genetic Position: Chr1, 22.33 cM
• Alliance: Fhl2^em1Huag page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR/cas9 mediated recombination using guide RNAs resulted in deletion of exons 3-5. Western blot analysis confirmed the absence of protein expression in whole ovary extracts from homozygous female mice. (J:360852)
• Inheritance: Not Specified

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Fhl2 Mutation: 18 strains or lines available

References

• Original: J:360852 Wang C, et al., FHL2 deficiency impairs follicular development and fertility by attenuating EGF/EGFR/YAP signaling in ovarian granulosa cells. Cell Death Dis. 2023 Apr 5;14(4):239
• All: 1 reference(s)