Del(5Pilrb1-Pilrb2)1Asw
Endonuclease-mediated Allele Detail

Summary

• Symbol: Del(5Pilrb1-Pilrb2)1Asw
• Name: deletion, chr 5, Anand Swaroop 1
• MGI ID: MGI:8242612
• Synonyms: Pilrb1/2^-
• Gene: Del(5Pilrb1-Pilrb2)1Asw Location: unknown Genetic Position: Chr5, Syntenic

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intergenic deletion
• Del(5Pilrb1-Pilrb2)1Asw involves 3 genes/genome features (Pilrb1, Pilrb2, Gm43495) View all
• Mutation details: CRISPR-targeting deleted 14.1 kb encompassing the promoter, exons 1 and 2 of Pilrb1 gene, and the entire Pilrb2 genomic sequence. Immunoblot analysis using a rabbit anti-PILRB antibody confirmed the absence of both PILRB proteins in the retina of homozygous mutant mice. (J:363577)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Del(5Pilrb1-Pilrb2)1Asw Mutation: 0 strains or lines available

References

• Original: J:363577 Dey PN, et al., Loss of paired immunoglobin-like type 2 receptor B gene associated with age-related macular degeneration impairs photoreceptor function in mouse retina. Hum Mol Genet. 2025 Jan 23;34(1):64-76
• All: 1 reference(s)