Trdnos^em1Ksng
Endonuclease-mediated Allele Detail

Summary

• Symbol: Trdnos^em1Ksng
• Name: triadin, opposite strand; endonuclease-mediated mutation 1, Kunhua Song
• MGI ID: MGI:8240112
• Synonyms: Trdn-as^-
• Gene: Trdnos Location: Chr10:33098341-33132353 bp, - strand Genetic Position: Chr10, Syntenic
• Alliance: Trdnos^em1Ksng page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• Mutation details: CRISPR-targeting deleted exons 2 and 3. qPCR analysis confirmed the absence of expression in homozygous mutant hearts. The coding sequence of the Trdn (triadin) gene is not altered. (J:364653)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Trdnos Mutation: 0 strains or lines available

References

• Original: J:364653 Zhao Y, et al., Cardiomyocyte-Specific Long Noncoding RNA Regulates Alternative Splicing of the Triadin Gene in the Heart. Circulation. 2022 Aug 30;146(9):699-714
• All: 1 reference(s)