Ddit4l^em1Omunc
Endonuclease-mediated Allele Detail

Summary

• Symbol: Ddit4l^em1Omunc
• Name: DNA-damage-inducible transcript 4-like; endonuclease-mediated mutation 1, Naoki Harada
• MGI ID: MGI:8224528
• Synonyms: Redd2-KO
• Gene: Ddit4l Location: Chr3:137329433-137334093 bp, + strand Genetic Position: Chr3, 63.81 cM
• Alliance: Ddit4l^em1Omunc page

Mutation origin

• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Intragenic deletion
• CRISPR/Cas9 genome editing technology was used to generate a 381 bp deletion encompassing exon 2. (J:370104)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Ddit4l Mutation: 12 strains or lines available

References

• Original: J:370104 Yamada Y, et al., Nrf2-and p53-inducible REDD2/DDiT4L/Rtp801L confers pancreatic beta-cell dysfunction, leading to glucose intolerance in high-fat diet-fed mice. J Biol Chem. 2025 May 21;301(6):110271
• All: 1 reference(s)