Tg(Kitl-cre/ERT2,-tdTomato)1Nerl
Transgene Detail

Summary

• Symbol: Tg(Kitl-cre/ERT2,-tdTomato)1Nerl
• Name: transgene insertion 1, Claus Nerlov
• MGI ID: MGI:8224272
• Synonyms: Kitl-tdTomato
• Transgene: Tg(Kitl-cre/ERT2,-tdTomato)1Nerl Location: unknown
• Alliance: Tg(Kitl-cre/ERT2,-tdTomato)1Nerl page

Transgene origin

• Strain of Origin: Not Specified

Transgene description

• Transgene Type: Transgenic (Recombinase, Reporter)
• Mutation: Insertion
• Tg(Kitl-cre/ERT2,-tdTomato)1Nerl expression driven by 1 gene
  Transgene expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Kitl (MGI:96974)

• Mutation details: A transgenic mouse BAC construct containing the Kitl ATG and the remainder of exon 1 with a cassette composed of a hybrid intron (to allow for a controlled splicing event), a Kozak-ATG-CreERT2 moiety, an IRES followed by a myristoylated tdTomato dimer, and a SV40 polyA site was used to generate transgenic mice. (J:274571)

Recombinase activity

Activity:	Tissue activity of this recombinase allele
Driver:	Kitl (mouse) Summary of all recombinase alleles driven by Kitl. Alliance mouse Kitl gene page

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available

References

• Original: J:274571 Buono M, et al., A dynamic niche provides Kit ligand in a stage-specific manner to the earliest thymocyte progenitors. Nat Cell Biol. 2016 Feb;18(2):157-67
• All: 3 reference(s)