Scn11a^{tm1(tetO)Frbo}
Targeted Allele Detail

Summary

• Symbol: Scn11a^{tm1(tetO)Frbo}
• Name: sodium channel, voltage-gated, type XI, alpha; targeted mutation 1, Frank Bosmans
• MGI ID: MGI:8214713
• Synonyms: NaV1.9^-, NaV1.9^- FAST
• Gene: Scn11a Location: Chr9:119582829-119654522 bp, - strand Genetic Position: Chr9, 71.33 cM, cytoband F3-F4
• Alliance: Scn11a^{tm1(tetO)Frbo} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:270913
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, Inducible, Null/knockout)
• Inducer: doxycycline/tetracycline
• Mutation: Insertion
• Mutation details: The flexible accelerated Neo-STOP tetracycline-inducible (FAST) technique inserted the superfolder green fluorescent protein (sfGFP), a GFP with enhanced folding kinetics, after the endogenous start codon. The knock-in cassette also contains a loxP-FRT-Neo-STOP-FRT-tetO-loxP upstream of the start codon and sfGFP insertion which produces a global knock-out allele. (J:270913)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Scn11a Mutation: 88 strains or lines available

References

• Original: J:270913 Salvatierra J, et al., A disease mutation reveals a role for NaV1.9 in acute itch. J Clin Invest. 2018 Dec 3;128(12):5434-5447
• All: 2 reference(s)