Zbtb11^tm1.1Lieg
Targeted Allele Detail

Summary

• Symbol: Zbtb11^tm1.1Lieg
• Name: zinc finger and BTB domain containing 11; targeted mutation 1.1, Graham J Lieschke
• MGI ID: MGI:8213606
• Synonyms: Zbtb11^fl
• Gene: Zbtb11 Location: Chr16:55794246-55829276 bp, + strand Genetic Position: Chr16, 33.74 cM
• Alliance: Zbtb11^tm1.1Lieg page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:343208
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready)
• Mutation: Insertion
• Mutation details: A loxP site was inserted upstream of exon 2 and an frt flanked pgk-neo cassette and loxP site were inserted downstream of exon 2 via homologous recombination. Flp mediated recombination removed the pgk-neo cassette. (J:343208)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Zbtb11 Mutation: 28 strains or lines available

References

• Original: J:343208 Cao H, et al., Late fetal hematopoietic failure results from ZBTB11 deficiency despite abundant HSC specification. Blood Adv. 2023 Nov 14;7(21):6506-6519
• All: 1 reference(s)