Nwd1^em2Sisa
Endonuclease-mediated Allele Detail

Summary

• Symbol: Nwd1^em2Sisa
• Name: NACHT and WD repeat domain containing 1; endonuclease-mediated mutation 2, Shin-ichi Sakakibara
• MGI ID: MGI:8203527
• Synonyms: Nwd1^flox
• Gene: Nwd1 Location: Chr8:73372865-73443508 bp, + strand Genetic Position: Chr8, 35.08 cM
• Alliance: Nwd1^em2Sisa page

Mutation origin

• Strain of Origin: B6;D2-Nwd1^em1Sisa/Sisa

Mutation description

• Allele Type: Endonuclease-mediated (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A right loxP site was introduced into intron 5 via CRISPR/Cas9 technology in male-derived zygotes that contain Nwd1^em1Sisa which have a loxP site in intron 4. This generates a conditional allele in which exon 5 is flanked by loxP sites. (J:363603)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nwd1 Mutation: 74 strains or lines available

References

• Original: J:363603 Yamada S, et al., Induction of MASH-like pathogenesis in the Nwd1(-/-) mouse liver. Commun Biol. 2025 Mar 11;8(1):348
• All: 1 reference(s)