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Nwd1em1Sisa
Endonuclease-mediated Allele Detail
Summary
Symbol: Nwd1em1Sisa
Name: NACHT and WD repeat domain containing 1; endonuclease-mediated mutation 1, Shin-ichi Sakakibara
MGI ID: MGI:8203525
Gene: Nwd1  Location: Chr8:73372865-73443508 bp, + strand  Genetic Position: Chr8, 35.08 cM
Alliance: Nwd1em1Sisa page
Mutation
origin
Strain of Origin:  (C57BL/6 x DBA/2)F2
Mutation
description
Allele Type:    Endonuclease-mediated (No functional change)
Mutation:    Insertion
    A left loxP site was introduced into intron 4 via CRISPR/Cas9 technology. (J:363603)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nwd1 Mutation:  74 strains or lines available
Notes
This allele was used to generate the Nwd1em2Sisa allele.
References
Original:  J:363603 Yamada S, et al., Induction of MASH-like pathogenesis in the Nwd1(-/-) mouse liver. Commun Biol. 2025 Mar 11;8(1):348
All:  1 reference(s)
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Funding Information
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory