Grb7^tm1Ward
Targeted Allele Detail

Summary

• Symbol: Grb7^tm1Ward
• Name: growth factor receptor bound protein 7; targeted mutation 1, Andrew Ward
• MGI ID: MGI:7797776
• Gene: Grb7 Location: Chr11:98337660-98346199 bp, + strand Genetic Position: Chr11, 61.75 cM
• Alliance: Grb7^tm1Ward page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:355260
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• The targeting construct replaced exons 2 through 15 with a neomycin resistance cassette. (J:355260)

Expression

In Mice Carrying this Mutation:

2 assay results

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Grb7 Mutation: 17 strains or lines available

References

• Original: J:355260 Moorwood K, et al., Grb7, Grb10 and Grb14, encoding the growth factor receptor-bound 7 family of signalling adaptor proteins have overlapping functions in the regulation of fetal growth and post-natal glucose metabolism. BMC Biol. 2024 Sep 30;22(1):221
• All: 1 reference(s)