Igs2^{em2(Alb-TTR*V50M)Cya}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Igs2^{em2(Alb-TTR*V50M)Cya}
• Name: intergenic site 2; endonuclease-mediated mutation 2, Cyagen Biosciences
• MGI ID: MGI:7657267
• Synonyms: Igs2^{em1(Alb-hTTR*V50M)}
• Gene: Igs2 Location: Chr11:3195460-3195497 bp Genetic Position: Chr11, Syntenic
• Alliance: Igs2^{em2(Alb-TTR*V50M)Cya} page

Mutation origin

• Strain of Origin: C57BL/6N

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Igs2^{em2(Alb-TTR*V50M)Cya} expresses 1 gene
  Knock-in expresses:
  

  Organism

  Expressed Gene

  Homolog in Mouse

  Note

  human

  TTR (7276)

  Ttr	(MGI:98865)

• Igs2^{em2(Alb-TTR*V50M)Cya} expression driven by 1 gene
  Knock-in expression driven by:
  

  Organism	Driver Gene	Note
  mouse	Alb (MGI:87991)

• Mutation details: The Alb promoter-Human TTR Genomic DNA (exon 1 to ~0.5kb downstream of exon 4) cassette was inserted into the H11 locus (Approx 0.7kb upstream of the Eif4enif1 gene and 4.5kb downstream of the Drg1 gene). The p.V50M (GTG to ATG) point mutation was introduced into human TTR exon 2. (J:326541)
• Inheritance: Not Specified

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igs2 Mutation: 72 strains or lines available

References

• Original: J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022
• All: 1 reference(s)