Hmgxb4^tm1.2Zhji
Targeted Allele Detail

Summary

• Symbol: Hmgxb4^tm1.2Zhji
• Name: HMG box domain containing 4; targeted mutation 1.2, Jiliang Zhou
• MGI ID: MGI:7643694
• Gene: Hmgxb4 Location: Chr8:75720305-75758606 bp, + strand Genetic Position: Chr8, 35.57 cM
• Alliance: Hmgxb4^tm1.2Zhji page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:302603
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: C57BL/6J

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A gene trap consisting of a loxP site, an FRT flanked-cassette containing En2 spicing acceptor, IRES, lacZ, pA, hBactP, neomycin resistance gene, and pA, followed by exons 3 to 5, and a second loxP site was inserted after exon 2. The En2 SA/LacZ/neo cassette was removed via flp-mediated recombination. Exons 3-5 were deleted via cre-mediated recombination in the germline. (J:302603)

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hmgxb4 Mutation: 66 strains or lines available

References

• Original: J:302603 He X, et al., Deficiency of the novel high mobility group protein HMGXB4 protects against systemic inflammation-induced endotoxemia in mice. Proc Natl Acad Sci U S A. 2021 Feb 16;118(7):e2021862118
• All: 1 reference(s)