Gm38999^em1Doca
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gm38999^em1Doca
• Name: predicted gene, 38999; endonuclease-mediated mutation 1, Donal O'Carroll
• MGI ID: MGI:7625636
• Synonyms: C19orf84^-, C19orf84-null
• Gene: Gm38999 Location: Chr7:43077110-43078256 bp, + strand Genetic Position: Chr7, Syntenic
• Alliance: Gm38999^em1Doca page

Mutation origin

• Strain of Origin: (C57BL/6J x CBA/CaCrl)F1

Mutation description

• Allele Type: Endonuclease-mediated (Null/knockout)
• Mutation: Insertion
• Mutation details: CRISPR-targeting of exon 1 produced a 2 bp insertion that results in a frame shift and premature termination. Western blot analysis confirmed the absence of protein expression in fetal testes from E16.5 homozygous mutant males. (J:346376)

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gm38999 Mutation: 0 strains or lines available

References

• Original: J:346376 Zoch A, et al., C19ORF84 connects piRNA and DNA methylation machineries to defend the mammalian germ line. Mol Cell. 2024 Mar 21;84(6):1021-1035.e11
• All: 1 reference(s)