Gt(ROSA)26Sor^{em1(Ube2s)Chaw}
Endonuclease-mediated Allele Detail

Summary

• Symbol: Gt(ROSA)26Sor^{em1(Ube2s)Chaw}
• Name: gene trap ROSA 26, Philippe Soriano; endonuclease-mediated mutation 1, Changjiang Weng
• MGI ID: MGI:7621224
• Synonyms: Ube2s^transgene
• Gene: Gt(ROSA)26Sor Location: Chr6:113044389-113054205 bp, - strand Genetic Position: Chr6, 52.73 cM
• Alliance: Gt(ROSA)26Sor^{em1(Ube2s)Chaw} page

Mutation origin

• Strain of Origin: Not Specified

Mutation description

• Allele Type: Endonuclease-mediated (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: CRISPR/cas9 mediated recombination inserted a construct contain a splice acceptor site, Ube2s gene, and BGH sequence. (J:306461)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Gt(ROSA)26Sor Mutation: 944 strains or lines available

References

• Original: J:306461 Huang L, et al., Ubiquitin-Conjugating Enzyme 2S Enhances Viral Replication by Inhibiting Type I IFN Production through Recruiting USP15 to Deubiquitinate TBK1. Cell Rep. 2020 Aug 18;32(7):108044
• All: 1 reference(s)